1-cycloheptyl-1-[4-(4-fluoro-phenoxy)-benzyl]-3-(2-methoxy-6-methyl-4-methylsulfanyl-pyridin-3-yl)-urea

Base Information

Chemical Name:1-cycloheptyl-1-[4-(4-fluoro-phenoxy)-benzyl]-3-(2-methoxy-6-methyl-4-methylsulfanyl-pyridin-3-yl)-urea
CAS No.:179054-93-4
Molecular Formula:C₂₉H₃₄FN₃O₃S
Molecular Weight:523.672
Hs Code.:

Synonyms:1-cycloheptyl-1-[4-(4-fluoro-phenoxy)-benzyl]-3-(2-methoxy-6-methyl-4-methylsulfanyl-pyridin-3-yl)-urea

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Chemical Property of 1-cycloheptyl-1-[4-(4-fluoro-phenoxy)-benzyl]-3-(2-methoxy-6-methyl-4-methylsulfanyl-pyridin-3-yl)-urea

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Technology Process of 1-cycloheptyl-1-[4-(4-fluoro-phenoxy)-benzyl]-3-(2-methoxy-6-methyl-4-methylsulfanyl-pyridin-3-yl)-urea

There total 5 articles about 1-cycloheptyl-1-[4-(4-fluoro-phenoxy)-benzyl]-3-(2-methoxy-6-methyl-4-methylsulfanyl-pyridin-3-yl)-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 179055-52-8
N-cycloheptyl-4-(4-fluorophenoxy)benzylamine

: 179057-07-9
phenyl N-<2-methoxy-6-methyl-4-(methylthio)pyridin-3-yl>carbamate

: 179054-93-4
1-cycloheptyl-1-[4-(4-fluoro-phenoxy)-benzyl]-3-(2-methoxy-6-methyl-4-methylsulfanyl-pyridin-3-yl)-urea

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 100 ℃; for 3h;
DOI:10.1021/jm980399q

Reference yield:

: 63897-12-1
2,4-dichloro-6-methyl-3-nitropyridine

: 179054-93-4
1-cycloheptyl-1-[4-(4-fluoro-phenoxy)-benzyl]-3-(2-methoxy-6-methyl-4-methylsulfanyl-pyridin-3-yl)-urea

Guidance literature:: Multi-step reaction with 5 steps

1: 76 percent / methanol / 5 h / Ambient temperature

2: 79 percent / methanol / 7 h / Heating

3: 87 percent / H₂ / 10 percent Pd/C / dioxane; methanol / 3 h / 760 Torr

4: 52 percent / N,N-dimethylaniline / CH₂Cl₂ / 3 h / Ambient temperature

5: 50 percent / Et₃N / dimethylformamide / 3 h / 100 °C

With hydrogen; N,N-dimethyl-aniline; triethylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980399q

Reference yield:

: 179057-09-1
2-chloro-6-methyl-4-(methylthio)-3-nitropyridine

: 179054-93-4
1-cycloheptyl-1-[4-(4-fluoro-phenoxy)-benzyl]-3-(2-methoxy-6-methyl-4-methylsulfanyl-pyridin-3-yl)-urea

Guidance literature:: Multi-step reaction with 4 steps

1: 79 percent / methanol / 7 h / Heating

2: 87 percent / H₂ / 10 percent Pd/C / dioxane; methanol / 3 h / 760 Torr

3: 52 percent / N,N-dimethylaniline / CH₂Cl₂ / 3 h / Ambient temperature

4: 50 percent / Et₃N / dimethylformamide / 3 h / 100 °C

With hydrogen; N,N-dimethyl-aniline; triethylamine; palladium on activated charcoal; In 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm980399q