ethyl 2-[(R)-(4-chlorophenyl){[(R)-1-(4-methoxyphenyl)ethyl]amino}methyl]acrylate

Base Information

Chemical Name:ethyl 2-[(R)-(4-chlorophenyl){[(R)-1-(4-methoxyphenyl)ethyl]amino}methyl]acrylate
CAS No.:1361200-82-9
Molecular Formula:C₂₁H₂₄ClNO₃
Molecular Weight:373.879
Hs Code.:

Synonyms:ethyl 2-[(R)-(4-chlorophenyl){[(R)-1-(4-methoxyphenyl)ethyl]amino}methyl]acrylate

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Chemical Property of ethyl 2-[(R)-(4-chlorophenyl){[(R)-1-(4-methoxyphenyl)ethyl]amino}methyl]acrylate

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Technology Process of ethyl 2-[(R)-(4-chlorophenyl){[(R)-1-(4-methoxyphenyl)ethyl]amino}methyl]acrylate

There total 8 articles about ethyl 2-[(R)-(4-chlorophenyl){[(R)-1-(4-methoxyphenyl)ethyl]amino}methyl]acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 6298-96-0,22038-86-4,35600-82-9,41851-59-6
1(R)-(4-methoxyphenyl)-ethylamine

: 134294-33-0
ethyl-(2Z)-2-(bromomethyl)-3-(4-chlorophenyl)-propenoate

: 1361200-82-9
ethyl 2-[(R)-(4-chlorophenyl){[(R)-1-(4-methoxyphenyl)ethyl]amino}methyl]acrylate

Guidance literature:: ethyl-(2Z)-2-(bromomethyl)-3-(4-chlorophenyl)-propenoate; With quinindine; In dichloromethane; at 20 ℃; for 3h;

1(R)-(4-methoxyphenyl)-ethylamine; In dichloromethane; at 0 ℃; for 1h; diastereoselective reaction;
DOI:10.1002/ejoc.201101244

Reference yield:

: 6298-96-0,22038-86-4,35600-82-9,41851-59-6
1(R)-(4-methoxyphenyl)-ethylamine

: 134294-33-0
ethyl-(2Z)-2-(bromomethyl)-3-(4-chlorophenyl)-propenoate

: 1361200-80-7
ethyl 2-[(S)-(4-chlorophenyl){[(R)-1-(4-methoxyphenyl)ethyl]amino}methyl]acrylate

: 1361200-82-9
ethyl 2-[(R)-(4-chlorophenyl){[(R)-1-(4-methoxyphenyl)ethyl]amino}methyl]acrylate

Guidance literature:: ethyl-(2Z)-2-(bromomethyl)-3-(4-chlorophenyl)-propenoate; With quinine; In dichloromethane; at 20 ℃; for 3h;

1(R)-(4-methoxyphenyl)-ethylamine; In dichloromethane; at 0 ℃; for 1h; optical yield given as %de; diastereoselective reaction;
DOI:10.1002/ejoc.201101244

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 1361200-82-9
ethyl 2-[(R)-(4-chlorophenyl){[(R)-1-(4-methoxyphenyl)ethyl]amino}methyl]acrylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: 1,4-diaza-bicyclo[2.2.2]octane; N,N-dimethyl-formamide / dimethyl sulfoxide / 20 °C

2.1: sulfuric acid; lithium bromide / dichloromethane / 0 - 20 °C

3.1: quinindine / dichloromethane / 3 h / 20 °C

3.2: 1 h / 0 °C

With 1,4-diaza-bicyclo[2.2.2]octane; sulfuric acid; quinindine; N,N-dimethyl-formamide; lithium bromide; In dichloromethane; dimethyl sulfoxide; 1.1: Morita-Baylis-Hillman reaction;
DOI:10.1002/ejoc.201101244