Technology Process of N-[(2R,4aS,8aS)-4-[(3,5-dihydroxyphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl]-3-aminopropanamide
There total 11 articles about N-[(2R,4aS,8aS)-4-[(3,5-dihydroxyphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl]-3-aminopropanamide which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
trifluoroacetic acid;
In
dichloromethane;
at 20 ℃;
for 0.833333h;
Inert atmosphere;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: pyridinium chlorochromate / dichloromethane / 2 h / 20 °C
2.1: tin(IV) chloride / dichloromethane / 0.17 h / 0 °C / Inert atmosphere
3.1: borane-THF / tetrahydrofuran / 1.67 h / 0 - 20 °C / Inert atmosphere
3.2: 1.33 h / 0 - 65 °C
4.1: pyridinium chlorochromate / dichloromethane / 4 h / 20 °C
5.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 22.5 h / 20 °C / Inert atmosphere
6.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol; water / 23 h / 20 °C / 760.05 Torr
7.1: boron tribromide / dichloromethane / 3.5 h / -78 - 20 °C / Inert atmosphere
7.2: 0.67 h / 85 °C
8.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere
9.1: trifluoroacetic acid / dichloromethane / 0.83 h / 20 °C / Inert atmosphere
With
hydrogenchloride; borane-THF; palladium 10% on activated carbon; hydrogen; boron tribromide; tin(IV) chloride; sodium tris(acetoxy)borohydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; trifluoroacetic acid;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: tin(IV) chloride / dichloromethane / 0.17 h / 0 °C / Inert atmosphere
2.1: borane-THF / tetrahydrofuran / 1.67 h / 0 - 20 °C / Inert atmosphere
2.2: 1.33 h / 0 - 65 °C
3.1: pyridinium chlorochromate / dichloromethane / 4 h / 20 °C
4.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 22.5 h / 20 °C / Inert atmosphere
5.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / methanol; water / 23 h / 20 °C / 760.05 Torr
6.1: boron tribromide / dichloromethane / 3.5 h / -78 - 20 °C / Inert atmosphere
6.2: 0.67 h / 85 °C
7.1: N-ethyl-N,N-diisopropylamine; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate / N,N-dimethyl-formamide / 16 h / 20 °C / Inert atmosphere
8.1: trifluoroacetic acid / dichloromethane / 0.83 h / 20 °C / Inert atmosphere
With
hydrogenchloride; borane-THF; palladium 10% on activated carbon; hydrogen; boron tribromide; tin(IV) chloride; sodium tris(acetoxy)borohydride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; acetic acid; N-ethyl-N,N-diisopropylamine; pyridinium chlorochromate; trifluoroacetic acid;
In
tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide;
![tert-butyl N-(2-{[(2R,3S,4S,4aS,8aS)-4-[(3,5-dihydroxyphenyl)carbonyl]-3,4a,8,8-tetramethyldecahydronaphthalen-2-yl]carbamoyl}ethyl)carbamate](/Databaselist/images/loading.webp)
