7-Benzyl-8-(4-benzyloxymethyl-benzo[1,3]dioxol-5-yl)-8,9-dihydro-7H-[1,3]dioxolo[4,5-f]isoquinolin-6-one

Base Information

Chemical Name:7-Benzyl-8-(4-benzyloxymethyl-benzo[1,3]dioxol-5-yl)-8,9-dihydro-7H-[1,3]dioxolo[4,5-f]isoquinolin-6-one
CAS No.:219474-40-5
Molecular Formula:C₃₂H₂₇NO₆
Molecular Weight:521.569
Hs Code.:

Synonyms:7-Benzyl-8-(4-benzyloxymethyl-benzo[1,3]dioxol-5-yl)-8,9-dihydro-7H-[1,3]dioxolo[4,5-f]isoquinolin-6-one

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Chemical Property of 7-Benzyl-8-(4-benzyloxymethyl-benzo[1,3]dioxol-5-yl)-8,9-dihydro-7H-[1,3]dioxolo[4,5-f]isoquinolin-6-one

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Technology Process of 7-Benzyl-8-(4-benzyloxymethyl-benzo[1,3]dioxol-5-yl)-8,9-dihydro-7H-[1,3]dioxolo[4,5-f]isoquinolin-6-one

There total 11 articles about 7-Benzyl-8-(4-benzyloxymethyl-benzo[1,3]dioxol-5-yl)-8,9-dihydro-7H-[1,3]dioxolo[4,5-f]isoquinolin-6-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 44.0%

: (8S,9R)-7-Benzyl-8-(4-benzyloxymethyl-benzo[1,3]dioxol-5-yl)-6-oxo-6,7,8,9-tetrahydro-[1,3]dioxolo[4,5-f]isoquinoline-9-carboxylic acid

: 219474-40-5
7-Benzyl-8-(4-benzyloxymethyl-benzo[1,3]dioxol-5-yl)-8,9-dihydro-7H-[1,3]dioxolo[4,5-f]isoquinolin-6-one

Guidance literature:: In dimethyl sulfoxide; at 160 ℃; for 0.5h;

Reference yield:

: 70946-12-2
4-Methyl-benzo[1,3]dioxole-5-carboxylic acid diethylamide

: 219474-40-5
7-Benzyl-8-(4-benzyloxymethyl-benzo[1,3]dioxol-5-yl)-8,9-dihydro-7H-[1,3]dioxolo[4,5-f]isoquinolin-6-one

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) n-BuLi, TMEDA / 1.) THF, hexane, -78 deg C, 0.5 h, 2.) THF, hexane, -78 deg C to rt

2: 77 percent / aq. HClO₄ / 18 h / Heating

3: 96 percent / AcCl / 6 h / Heating

4: 61 percent / acetonitrile / 12 h / Ambient temperature

5: 44 percent / dimethylsulfoxide / 0.5 h / 160 °C

With n-butyllithium; perchloric acid; N,N,N,N,-tetramethylethylenediamine; acetyl chloride; In dimethyl sulfoxide; acetonitrile;

Reference yield:

: 75267-17-3
5-Formyl-benzo[1,3]dioxole-4-carboxylic acid ethyl ester

: 219474-40-5
7-Benzyl-8-(4-benzyloxymethyl-benzo[1,3]dioxol-5-yl)-8,9-dihydro-7H-[1,3]dioxolo[4,5-f]isoquinolin-6-one

Guidance literature:: Multi-step reaction with 7 steps

1: 99 percent / BF₃*Et₂O / acetic acid / 12 h / Ambient temperature

2: 91 percent / LiAlH₄ / tetrahydrofuran / 18 h / Ambient temperature

3: 91 percent / NaH, TBA / tetrahydrofuran / 25 h / Ambient temperature

4: 99 percent / (CF₃CO₂)2IPh / acetonitrile; H₂O / Ambient temperature

5: 99 percent / benzene / 10 h / Heating

6: 61 percent / acetonitrile / 12 h / Ambient temperature

7: 44 percent / dimethylsulfoxide / 0.5 h / 160 °C

With lithium aluminium tetrahydride; boron trifluoride diethyl etherate; sodium hydride; tert-butylamine; bis-[(trifluoroacetoxy)iodo]benzene; In tetrahydrofuran; water; acetic acid; dimethyl sulfoxide; acetonitrile; benzene;