(3S,8aS)-6-Allyl-6-(3,4-dimethoxy-phenyl)-3-isopropyl-8a-methyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

Base Information

Chemical Name:(3S,8aS)-6-Allyl-6-(3,4-dimethoxy-phenyl)-3-isopropyl-8a-methyl-hexahydro-oxazolo[3,2-a]pyridin-5-one
CAS No.:99548-17-1
Molecular Formula:C₂₂H₃₁NO₄
Molecular Weight:373.492
Hs Code.:

Synonyms:(3S,8aS)-6-Allyl-6-(3,4-dimethoxy-phenyl)-3-isopropyl-8a-methyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

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Chemical Property of (3S,8aS)-6-Allyl-6-(3,4-dimethoxy-phenyl)-3-isopropyl-8a-methyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

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Technology Process of (3S,8aS)-6-Allyl-6-(3,4-dimethoxy-phenyl)-3-isopropyl-8a-methyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

There total 2 articles about (3S,8aS)-6-Allyl-6-(3,4-dimethoxy-phenyl)-3-isopropyl-8a-methyl-hexahydro-oxazolo[3,2-a]pyridin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 106-95-6
allyl bromide

: 99548-16-0,99603-20-0,99603-21-1,99603-22-2
(S)-6-(3,4-Dimethoxy-phenyl)-3-isopropyl-8a-methyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

: 99548-17-1
(3S,8aS)-6-Allyl-6-(3,4-dimethoxy-phenyl)-3-isopropyl-8a-methyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

: 99548-17-1
(3S,6R,8aR)-6-Allyl-6-(3,4-dimethoxy-phenyl)-3-isopropyl-8a-methyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

Guidance literature:: With sec.-butyllithium; In tetrahydrofuran; at -20 ℃;
DOI:10.1021/ja00311a100

Reference yield: 90.0%

: 106-95-6
allyl bromide

: 99548-16-0,99603-20-0,99603-21-1,99603-22-2
(S)-6-(3,4-Dimethoxy-phenyl)-3-isopropyl-8a-methyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

: 99548-17-1
(3S,8aS)-6-Allyl-6-(3,4-dimethoxy-phenyl)-3-isopropyl-8a-methyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

: 99548-17-1
(3S,6R,8aR)-6-Allyl-6-(3,4-dimethoxy-phenyl)-3-isopropyl-8a-methyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

Guidance literature:: With sec.-butyllithium; In tetrahydrofuran; at -20 ℃;
DOI:10.1021/ja00311a100

Reference yield:

: 99548-17-1
(3S,6R,8aR)-6-Allyl-6-(3,4-dimethoxy-phenyl)-3-isopropyl-8a-methyl-hexahydro-oxazolo[3,2-a]pyridin-5-one

: 468-53-1
(3aR,7aR)-3a-(3,4-Dimethoxyphenyl)-1-methylhexahydro-1H-indol-6(2H)-one

Guidance literature:: Multi-step reaction with 5 steps

1: OsO₄, NaIO₄ / diethyl ether; H₂O / 8 h / 25 °C

2: CNBH₃(-)

3: LiAl(OEt)H₃ / 1,2-dimethoxy-ethane; toluene / -20 °C

4: Bu₄NH₂PO₄ / ethanol

5: 4N NaOH / Ambient temperature

With sodium hydroxide; sodium periodate; osmium(VIII) oxide; lithium monoethoxyaluminum hydride; cyanoborohydride; tetrabutylammonium dihydrogen phosphate; In 1,2-dimethoxyethane; diethyl ether; ethanol; water; toluene;
DOI:10.1021/ja00311a100