N-[5-[(1R)-2-[N-benzyl-[(1RS)-3,3-bis(4-methoxyphenyl)-1-methylpropyl]amino]-1-(triethylsilyloxy)-ethyl]-2-(benzyloxy)phenyl]methanesulfonamide

Base Information

• Chemical Name: N-[5-[(1R)-2-[N-benzyl-[(1RS)-3,3-bis(4-methoxyphenyl)-1-methylpropyl]amino]-1-(triethylsilyloxy)-ethyl]-2-(benzyloxy)phenyl]methanesulfonamide
• CAS No.: 259799-55-8
• Molecular Formula: C₄₇H₆₀N₂O₆SSi
• Molecular Weight: 809.155

Synonyms:N-[5-[(1R)-2-[N-benzyl-[(1RS)-3,3-bis(4-methoxyphenyl)-1-methylpropyl]amino]-1-(triethylsilyloxy)-ethyl]-2-(benzyloxy)phenyl]methanesulfonamide

Chemical Property of N-[5-[(1R)-2-[N-benzyl-[(1RS)-3,3-bis(4-methoxyphenyl)-1-methylpropyl]amino]-1-(triethylsilyloxy)-ethyl]-2-(benzyloxy)phenyl]methanesulfonamide

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Technology Process of N-[5-[(1R)-2-[N-benzyl-[(1RS)-3,3-bis(4-methoxyphenyl)-1-methylpropyl]amino]-1-(triethylsilyloxy)-ethyl]-2-(benzyloxy)phenyl]methanesulfonamide

There total 1 articles about N-[5-[(1R)-2-[N-benzyl-[(1RS)-3,3-bis(4-methoxyphenyl)-1-methylpropyl]amino]-1-(triethylsilyloxy)-ethyl]-2-(benzyloxy)phenyl]methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-benzyl-[3,3-bis(4-methoxyphenyl)-1-methylpropyl]amine (782425-77-8,757163-66-9,166961-22-4) + (R)-N-[5-[2-iodo-1-[(triethylsilyl)-oxy]ethyl]-2-(phenylmethoxy)phenyl]methanesulfonamide (246262-39-5) → N-[5-[(1R)-2-[N-benzyl-[(1RS)-3,3-bis(4-methoxyphenyl)-1-methylpropyl]amino]-1-(triethylsilyloxy)-ethyl]-2-(benzyloxy)phenyl]methanesulfonamide (259799-55-8)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran;

Reference yield:

N-[5-[(1R)-2-[N-benzyl-[(1RS)-3,3-bis(4-methoxyphenyl)-1-methylpropyl]amino]-1-(triethylsilyloxy)-ethyl]-2-(benzyloxy)phenyl]methanesulfonamide (259799-55-8) → N-[5-[(1R)-2-[N-benzyl-[(1RS)-3,3-bis(4-methoxyphenyl)-1-methylpropyl]amino]-1-hydroxyethyl]-2-(benzyloxy)phenyl]methanesulfonamide (259799-10-5)

Guidance literature:

With tetrabutyl ammonium fluoride; acetic acid; In tetrahydrofuran;

upstream raw materials:

N-benzyl-[3,3-bis(4-methoxyphenyl)-1-methylpropyl]amine

(R)-N-[5-[2-iodo-1-[(triethylsilyl)-oxy]ethyl]-2-(phenylmethoxy)phenyl]methanesulfonamide

Downstream raw materials:

N-[5-[(1R)-2-[N-benzyl-[(1RS)-3,3-bis(4-methoxyphenyl)-1-methylpropyl]amino]-1-hydroxyethyl]-2-(benzyloxy)phenyl]methanesulfonamide

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