Technology Process of 5-iodo-2-((2-nitrovinyl)amino)benzoic acid
There total 1 articles about 5-iodo-2-((2-nitrovinyl)amino)benzoic acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
nitromethane;
With
water; sodium hydroxide;
at 0 - 20 ℃;
for 2h;
2-Amino-5-iodo-benzoic acid; hydrochloride;
With
hydrogenchloride;
at 20 ℃;
Cooling;
- Guidance literature:
-
Multi-step reaction with 4 steps
1: acetic anhydride; potassium acetate / 2 h / 120 °C
2: trichlorophosphate / 0.67 h / 120 °C
3: triethylamine / dimethyl sulfoxide / 6 h / 20 - 50 °C
4: N-ethyl-N,N-diisopropylamine; copper(l) iodide / tetrakis(triphenylphosphine) palladium(0) / dimethyl sulfoxide / 0.5 h / 50 °C
With
copper(l) iodide; potassium acetate; acetic anhydride; triethylamine; N-ethyl-N,N-diisopropylamine; trichlorophosphate;
tetrakis(triphenylphosphine) palladium(0);
In
dimethyl sulfoxide;
- Guidance literature:
-
Multi-step reaction with 6 steps
1: potassium acetate; acetic anhydride / 2 h / 120 °C
2: trichlorophosphate / 0.67 h / 120 °C
3: ammonia / methanol; dichloromethane / 0 - 40 °C
4: iron; acetic acid / water / 6.5 h / 55 °C
5: formic acid / 0.33 h / 130 °C
6: copper(l) iodide; N-ethyl-N,N-diisopropylamine / tetrakis(triphenylphosphine) palladium(0) / dimethyl sulfoxide / 2 h / 85 °C / Inert atmosphere
With
copper(l) iodide; formic acid; ammonia; potassium acetate; acetic anhydride; iron; acetic acid; N-ethyl-N,N-diisopropylamine; trichlorophosphate;
tetrakis(triphenylphosphine) palladium(0);
In
methanol; dichloromethane; water; dimethyl sulfoxide;
