2R-(2,2-dimethyl-5-oxo-[1,3]dioxolan-4S-yl)-4-methyl-pentanoic acid [2,2-dimethyl-1S-(5-phenyl-[1,2,4]oxadiazol-3-yl)-propyl]-amide

Base Information

Chemical Name:2R-(2,2-dimethyl-5-oxo-[1,3]dioxolan-4S-yl)-4-methyl-pentanoic acid [2,2-dimethyl-1S-(5-phenyl-[1,2,4]oxadiazol-3-yl)-propyl]-amide
CAS No.:586972-70-5
Molecular Formula:C₂₄H₃₃N₃O₅
Molecular Weight:443.543
Hs Code.:

Synonyms:2R-(2,2-dimethyl-5-oxo-[1,3]dioxolan-4S-yl)-4-methyl-pentanoic acid [2,2-dimethyl-1S-(5-phenyl-[1,2,4]oxadiazol-3-yl)-propyl]-amide

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Chemical Property of 2R-(2,2-dimethyl-5-oxo-[1,3]dioxolan-4S-yl)-4-methyl-pentanoic acid [2,2-dimethyl-1S-(5-phenyl-[1,2,4]oxadiazol-3-yl)-propyl]-amide

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Technology Process of 2R-(2,2-dimethyl-5-oxo-[1,3]dioxolan-4S-yl)-4-methyl-pentanoic acid [2,2-dimethyl-1S-(5-phenyl-[1,2,4]oxadiazol-3-yl)-propyl]-amide

There total 8 articles about 2R-(2,2-dimethyl-5-oxo-[1,3]dioxolan-4S-yl)-4-methyl-pentanoic acid [2,2-dimethyl-1S-(5-phenyl-[1,2,4]oxadiazol-3-yl)-propyl]-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 2,2-dimethyl-1S-(5-phenyl-[1,2,4]oxadiazol-3-yl)-propylamine

: 157518-71-3
2R-(2,2-dimethyl-5-oxo-[1,3]dioxolan-4S-yl)-4-methyl-pentanoic acid pentafluorophenyl ester

: 586972-70-5
2R-(2,2-dimethyl-5-oxo-[1,3]dioxolan-4S-yl)-4-methyl-pentanoic acid [2,2-dimethyl-1S-(5-phenyl-[1,2,4]oxadiazol-3-yl)-propyl]-amide

Guidance literature:: In DMF (N,N-dimethyl-formamide); at 0 - 20 ℃; for 15h;

Reference yield:

: 586972-65-8
(1S-cyano-2,2-dimethyl-propyl)-carbamic acid benzyl ester

: 586972-70-5
2R-(2,2-dimethyl-5-oxo-[1,3]dioxolan-4S-yl)-4-methyl-pentanoic acid [2,2-dimethyl-1S-(5-phenyl-[1,2,4]oxadiazol-3-yl)-propyl]-amide

Guidance literature:: Multi-step reaction with 4 steps

1: hydroxylamine / ethanol; water / 3 h / Heating / reflux

2: pyridine / dmap / DMF (N,N-dimethyl-formamide) / 20 h / 20 - 100 °C

3: hydrogen bromide / acetic acid / 3 h / 20 °C

4: DMF (N,N-dimethyl-formamide) / 15 h / 0 - 20 °C

With pyridine; hydrogen bromide; hydroxylamine; dmap; In DMF (N,N-dimethyl-formamide); ethanol; water; acetic acid;

Reference yield:

: 586972-66-9
[1S-(N-hydroxycarbamimidoyl)-2,2-dimethyl-propyl]-carbamic acid benzyl ester

: 586972-70-5
2R-(2,2-dimethyl-5-oxo-[1,3]dioxolan-4S-yl)-4-methyl-pentanoic acid [2,2-dimethyl-1S-(5-phenyl-[1,2,4]oxadiazol-3-yl)-propyl]-amide

Guidance literature:: Multi-step reaction with 3 steps

1: pyridine / dmap / DMF (N,N-dimethyl-formamide) / 20 h / 20 - 100 °C

2: hydrogen bromide / acetic acid / 3 h / 20 °C

3: DMF (N,N-dimethyl-formamide) / 15 h / 0 - 20 °C

With pyridine; hydrogen bromide; dmap; In DMF (N,N-dimethyl-formamide); acetic acid;