1H-Benzoimidazole-5-carboxylic acid {(1S,2S)-1-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-hydroxy-propyl}-amide

Base Information

Chemical Name:1H-Benzoimidazole-5-carboxylic acid {(1S,2S)-1-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-hydroxy-propyl}-amide
CAS No.:672292-17-0
Molecular Formula:C₃₃H₃₃N₃O₅
Molecular Weight:551.642
Hs Code.:

Synonyms:1H-Benzoimidazole-5-carboxylic acid {(1S,2S)-1-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-hydroxy-propyl}-amide

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Chemical Property of 1H-Benzoimidazole-5-carboxylic acid {(1S,2S)-1-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-hydroxy-propyl}-amide

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Technology Process of 1H-Benzoimidazole-5-carboxylic acid {(1S,2S)-1-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-hydroxy-propyl}-amide

There total 2 articles about 1H-Benzoimidazole-5-carboxylic acid {(1S,2S)-1-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-hydroxy-propyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 672291-98-4
N-(2-hydroxy-1-hydroxymethylpropyl)-1H-benzimidazole-5-carboxamide

: 672292-17-0
1H-Benzoimidazole-5-carboxylic acid {(1S,2S)-1-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-hydroxy-propyl}-amide

Guidance literature:: With pyridine; dmap; N-ethyl-N,N-diisopropylamine;
DOI:10.1002/chem.200305402

Reference yield:

: 15788-16-6
5-benzimidazolecarboxylic acid

: 672292-17-0
1H-Benzoimidazole-5-carboxylic acid {(1S,2S)-1-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-hydroxy-propyl}-amide

Guidance literature:: Multi-step reaction with 2 steps

1.1: DCC; HOBT / dimethylformamide; 1-methyl-pyrrolidin-2-one / 1 h / 20 °C

1.2: 93 percent / dimethylformamide; 1-methyl-pyrrolidin-2-one / 20 °C

2.1: 90 percent / DMAP; DIPEA; pyridine

With pyridine; dmap; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide;
DOI:10.1002/chem.200305402