4(3H)-Quinazolinone, 6-bromo-7-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, monohydrobromide

Base Information

Chemical Name:4(3H)-Quinazolinone, 6-bromo-7-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, monohydrobromide
CAS No.:17518-97-7
Molecular Formula:C16H18Br2ClN3O3
Molecular Weight:495.5934
Hs Code.:
DSSTox Substance ID:DTXSID70938629

Synonyms:CP 60949-4;CP-60949-4

Suppliers and Price of 4(3H)-Quinazolinone, 6-bromo-7-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, monohydrobromide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 2 raw suppliers

Chemical Property of 4(3H)-Quinazolinone, 6-bromo-7-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, monohydrobromide

Chemical Property:

Vapor Pressure:4.84E-15mmHg at 25°C
Boiling Point:595.8°Cat760mmHg
Flash Point:314.1°C
Density:g/cm³
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:494.93829
Heavy Atom Count:25
Complexity:533

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1CC(C(NC1)CC(=O)CN2C=NC3=CC(=C(C=C3C2=O)Br)Cl)O.Br

Technology Process of 4(3H)-Quinazolinone, 6-bromo-7-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, monohydrobromide

There total 14 articles about 4(3H)-Quinazolinone, 6-bromo-7-chloro-3-(3-(3-hydroxy-2-piperidinyl)-2-oxopropyl)-, monohydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₄H₂₃BrClN₃O₅

: 17518-97-7
trans-6-bromo-7-chloro-3-(3-(3-hydroxypiperidine-2-yl)-2-oxopropyl)quinazolin-4(3H)-one hydrobromide

Guidance literature:: With hydrogen bromide; acetic acid; In methanol; at 0 ℃; for 0.5h;
DOI:10.1039/c8ob00935j

Reference yield:

: 68471-58-9
1-(benzyloxycarbonyl)-1,2,3,4-tetrahydropyridine

: 17518-97-7
trans-6-bromo-7-chloro-3-(3-(3-hydroxypiperidine-2-yl)-2-oxopropyl)quinazolin-4(3H)-one hydrobromide

Guidance literature:: Multi-step reaction with 5 steps

1: Oxone; sodium hydrogencarbonate / acetone; water / 16 h / 20 °C

2: boron trifluoride diethyl etherate / dichloromethane / -78 - 20 °C / Inert atmosphere

3: potassium carbonate / acetonitrile / 16 h / Reflux

4: osmium(VIII) oxide; sodium periodate / water; tetrahydrofuran / 16 h / 20 °C

5: hydrogen bromide; acetic acid / methanol / 0.5 h / 0 °C

With Oxone; sodium periodate; osmium(VIII) oxide; boron trifluoride diethyl etherate; hydrogen bromide; sodium hydrogencarbonate; potassium carbonate; acetic acid; In tetrahydrofuran; methanol; dichloromethane; water; acetone; acetonitrile;
DOI:10.1039/c8ob00935j

Reference yield:

: benzyl 2-oxotetrahydro-[1,3]dioxolo[4,5-b]pyridine-4(3aH)-carboxylate

: 17518-97-7
trans-6-bromo-7-chloro-3-(3-(3-hydroxypiperidine-2-yl)-2-oxopropyl)quinazolin-4(3H)-one hydrobromide

Guidance literature:: Multi-step reaction with 4 steps

1: boron trifluoride diethyl etherate / dichloromethane / -78 - 20 °C / Inert atmosphere

2: potassium carbonate / acetonitrile / 16 h / Reflux

3: osmium(VIII) oxide; sodium periodate / water; tetrahydrofuran / 16 h / 20 °C

4: hydrogen bromide; acetic acid / methanol / 0.5 h / 0 °C

With sodium periodate; osmium(VIII) oxide; boron trifluoride diethyl etherate; hydrogen bromide; potassium carbonate; acetic acid; In tetrahydrofuran; methanol; dichloromethane; water; acetonitrile;
DOI:10.1039/c8ob00935j