C₂'-TBS-C₇-succinyl-paclitaxel-phe-phe-arg chloromethyl ketone

Base Information

• Chemical Name: C₂'-TBS-C₇-succinyl-paclitaxel-phe-phe-arg chloromethyl ketone
• CAS No.: 1221127-66-7
• Molecular Formula: C₂HF₃O₂*C₈₂H₁₀₀ClN₇O₁₉Si
• Molecular Weight: 1665.29
• Mol file: 1221127-66-7.mol

Synonyms:C₂'-TBS-C₇-succinyl-paclitaxel-phe-phe-arg chloromethyl ketone

Chemical Property of C₂'-TBS-C₇-succinyl-paclitaxel-phe-phe-arg chloromethyl ketone

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of C₂'-TBS-C₇-succinyl-paclitaxel-phe-phe-arg chloromethyl ketone

There total 1 articles about C₂'-TBS-C₇-succinyl-paclitaxel-phe-phe-arg chloromethyl ketone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

C57H69NO17Si (1093959-24-0) + 2C2HF3O2*C25H33ClN6O3 (649748-23-2) → C2'-TBS-C7-succinyl-paclitaxel-phe-phe-arg chloromethyl ketone (1221127-66-7)

Guidance literature:

C₅₇H₆₉NO₁₇Si; With N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline; In dichloromethane; at 20 ℃; for 0.5h; Inert atmosphere;

2C₂HF₃O₂*C₂₅H₃₃ClN₆O₃; With triethylamine; In dichloromethane; N,N-dimethyl-formamide; Inert atmosphere;

DOI:10.1021/jm901763f

Reference yield: 78.0%

C2'-TBS-C7-succinyl-paclitaxel-phe-phe-arg chloromethyl ketone (1221127-66-7) → 7-succinyl-paclitaxel-phe-phe-arg chloromethyl ketone (1221127-68-9)

Guidance literature:

With hydrogenchloride; In methanol;

DOI:10.1021/jm901763f

upstream raw materials:

C₅₇H₆₉NO₁₇Si

2C₂HF₃O₂*C₂₅H₃₃ClN₆O₃

Downstream raw materials:

7-succinyl-paclitaxel-phe-phe-arg chloromethyl ketone