(2S,4S,6S)-ethyl 6-ethyl-4-hydroxy-4-phenyltetrahydro-2H-pyran-2-carboxylate

Base Information

Chemical Name:(2S,4S,6S)-ethyl 6-ethyl-4-hydroxy-4-phenyltetrahydro-2H-pyran-2-carboxylate
CAS No.:1402854-19-6
Molecular Formula:C₁₆H₂₂O₄
Molecular Weight:278.348
Hs Code.:

Synonyms:(2S,4S,6S)-ethyl 6-ethyl-4-hydroxy-4-phenyltetrahydro-2H-pyran-2-carboxylate

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Chemical Property of (2S,4S,6S)-ethyl 6-ethyl-4-hydroxy-4-phenyltetrahydro-2H-pyran-2-carboxylate

Chemical Property:

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Technology Process of (2S,4S,6S)-ethyl 6-ethyl-4-hydroxy-4-phenyltetrahydro-2H-pyran-2-carboxylate

There total 2 articles about (2S,4S,6S)-ethyl 6-ethyl-4-hydroxy-4-phenyltetrahydro-2H-pyran-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 123-38-6
propionaldehyde

: 208242-82-4
ethyl (S)-2-hydroxy-4-phenylpent-4-enoate

: 1402854-19-6
(2S,4S,6S)-ethyl 6-ethyl-4-hydroxy-4-phenyltetrahydro-2H-pyran-2-carboxylate

Guidance literature:: With iron(III) chloride; tert-butyldimethylsilyl chloride; In dichloromethane; at 10 ℃; for 6h; stereoselective reaction;
DOI:10.1021/ja3062002

Reference yield:

: 98-83-9,6144-04-3,25014-31-7,42612-14-6
isopropenylbenzene

: 1402854-19-6
(2S,4S,6S)-ethyl 6-ethyl-4-hydroxy-4-phenyltetrahydro-2H-pyran-2-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: C₃₉H₆₀N₄O₄; nickel(II) tetrafluoroborate hexahydrate / dichloromethane / 48 h / 35 °C

2: iron(III) chloride; tert-butyldimethylsilyl chloride / dichloromethane / 6 h / 10 °C

With iron(III) chloride; C₃₉H₆₀N₄O₄; nickel(II) tetrafluoroborate hexahydrate; tert-butyldimethylsilyl chloride; In dichloromethane; 2: |Prins-Pinacol Rearrangement;
DOI:10.1021/ja3062002