{1-[2-(7-chloro-1H-pyrrolo[3,2-b]pyridin-3-yl)-2-oxo-acetyl]-piperidin-4-ylidene}-phenyl-acetonitrile

Base Information

• Chemical Name: {1-[2-(7-chloro-1H-pyrrolo[3,2-b]pyridin-3-yl)-2-oxo-acetyl]-piperidin-4-ylidene}-phenyl-acetonitrile
• CAS No.: 676490-39-4
• Molecular Formula: C₂₂H₁₇ClN₄O₂
• Molecular Weight: 404.856

Synonyms:{1-[2-(7-chloro-1H-pyrrolo[3,2-b]pyridin-3-yl)-2-oxo-acetyl]-piperidin-4-ylidene}-phenyl-acetonitrile

Chemical Property of {1-[2-(7-chloro-1H-pyrrolo[3,2-b]pyridin-3-yl)-2-oxo-acetyl]-piperidin-4-ylidene}-phenyl-acetonitrile

Chemical Property:

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Technology Process of {1-[2-(7-chloro-1H-pyrrolo[3,2-b]pyridin-3-yl)-2-oxo-acetyl]-piperidin-4-ylidene}-phenyl-acetonitrile

There total 1 articles about {1-[2-(7-chloro-1H-pyrrolo[3,2-b]pyridin-3-yl)-2-oxo-acetyl]-piperidin-4-ylidene}-phenyl-acetonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 11.0%

(7-chloro-1H-pyrrolo[3,2-b]pyridin-3-yl)-oxo-acetic acid (791053-66-2) + phenyl(piperidin-4-ylidene)acetonitrile (676490-69-0) → {1-[2-(7-chloro-1H-pyrrolo[3,2-b]pyridin-3-yl)-2-oxo-acetyl]-piperidin-4-ylidene}-phenyl-acetonitrile (676490-39-4)

Guidance literature:

With DEPBT; N-ethyl-N,N-diisopropylamine; In DMF (N,N-dimethyl-formamide); for 20h;

Reference yield: 39.0%

1,2,3-triazole (288-36-8) + {1-[2-(7-chloro-1H-pyrrolo[3,2-b]pyridin-3-yl)-2-oxo-acetyl]-piperidin-4-ylidene}-phenyl-acetonitrile (676490-39-4) → {1-[2-oxo-2-(7-[1,2,3]triazol-2-yl-1H-pyrrolo[3,2-b]pyridin-3-yl)-acetyl]-piperidin-4-ylidene}-phenyl-acetonitrile (676490-43-0)

Guidance literature:

With copper; potassium carbonate; at 160 ℃; for 5h;

Reference yield: 23.0%

{1-[2-(7-chloro-1H-pyrrolo[3,2-b]pyridin-3-yl)-2-oxo-acetyl]-piperidin-4-ylidene}-phenyl-acetonitrile (676490-39-4) + 5-tri-n-butylstannanypyrazine-2-ylamine (446285-53-6) → (1-{2-[7-(6-amino-pyrazin-2-yl)-1H-pyrrolo[3,2-b]pyridin-3-yl]-2-oxo-acetyl}-piperidin-4-ylidene)-phenyl-acetonitrile (676490-44-1)

Guidance literature:

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; at 160 ℃; for 0.5h;

upstream raw materials:

(7-chloro-1H-pyrrolo[3,2-b]pyridin-3-yl)-oxo-acetic acid

phenyl(piperidin-4-ylidene)acetonitrile

Downstream raw materials:

{1-[2-oxo-2-(7-thiazol-2-yl-1H-pyrrolo[3,2-b]pyridin-3-yl)-acetyl]-piperidin-4-ylidene}-phenyl-acetonitrile

{1-[2-oxo-2-(7-[1,2,3]triazol-2-yl-1H-pyrrolo[3,2-b]pyridin-3-yl)-acetyl]-piperidin-4-ylidene}-phenyl-acetonitrile

{1-[2-oxo-2-(7-pyrazin-2-yl-1H-pyrrolo[3,2-b]pyridin-3-yl)-acetyl]-piperidin-4-ylidene}-phenyl-acetonitrile

(1-{2-[7-(6-amino-pyrazin-2-yl)-1H-pyrrolo[3,2-b]pyridin-3-yl]-2-oxo-acetyl}-piperidin-4-ylidene)-phenyl-acetonitrile

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