methyl 5-(2-(4-fluorophenyl)-3-(methylcarbamoyl)pyrazolo[1,5-b]pyridazin-5-yl)-2-methoxy-4-methylbenzoate

Base Information

Chemical Name:methyl 5-(2-(4-fluorophenyl)-3-(methylcarbamoyl)pyrazolo[1,5-b]pyridazin-5-yl)-2-methoxy-4-methylbenzoate
CAS No.:1332519-25-1
Molecular Formula:C₂₄H₂₁FN₄O₄
Molecular Weight:448.454
Hs Code.:

Synonyms:methyl 5-(2-(4-fluorophenyl)-3-(methylcarbamoyl)pyrazolo[1,5-b]pyridazin-5-yl)-2-methoxy-4-methylbenzoate

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Chemical Property of methyl 5-(2-(4-fluorophenyl)-3-(methylcarbamoyl)pyrazolo[1,5-b]pyridazin-5-yl)-2-methoxy-4-methylbenzoate

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Technology Process of methyl 5-(2-(4-fluorophenyl)-3-(methylcarbamoyl)pyrazolo[1,5-b]pyridazin-5-yl)-2-methoxy-4-methylbenzoate

There total 4 articles about methyl 5-(2-(4-fluorophenyl)-3-(methylcarbamoyl)pyrazolo[1,5-b]pyridazin-5-yl)-2-methoxy-4-methylbenzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332519-21-7
methyl 5-(3-(tert-butoxycarbonyl(methyl)carbamoyl)-2-(4-fluorophenyl)pyrazolo[1,5-b]pyridazin-5-yl)-2-methoxy-4-methylbenzoate

: 1332519-25-1
methyl 5-(2-(4-fluorophenyl)-3-(methylcarbamoyl)pyrazolo[1,5-b]pyridazin-5-yl)-2-methoxy-4-methylbenzoate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 0.25h;

Reference yield:

: 1332519-02-4
3-(4-fluorophenyl)-N-methylpropiolamide

: 1332519-25-1
methyl 5-(2-(4-fluorophenyl)-3-(methylcarbamoyl)pyrazolo[1,5-b]pyridazin-5-yl)-2-methoxy-4-methylbenzoate

Guidance literature:: Multi-step reaction with 3 steps

1: dmap / tetrahydrofuran / 1 h

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 20.42 h / -78 - 20 °C

3: trifluoroacetic acid / dichloromethane / 0.25 h / 20 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; dmap; In tetrahydrofuran; dichloromethane;

Reference yield:

: 352-34-1
4-fluoro-1-iodobenzene

: 1332519-25-1
methyl 5-(2-(4-fluorophenyl)-3-(methylcarbamoyl)pyrazolo[1,5-b]pyridazin-5-yl)-2-methoxy-4-methylbenzoate

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide

2: dmap / tetrahydrofuran / 1 h

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / tetrahydrofuran / 20.42 h / -78 - 20 °C

4: trifluoroacetic acid / dichloromethane / 0.25 h / 20 °C

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; dmap; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; dichloromethane;