1-[(S)-(R)-3,3-Dichloro-3-fluoro-2-(3-methyl-but-2-enyloxy)-propane-1-sulfinyl]-4-methyl-benzene

Base Information

• Chemical Name: 1-[(S)-(R)-3,3-Dichloro-3-fluoro-2-(3-methyl-but-2-enyloxy)-propane-1-sulfinyl]-4-methyl-benzene
• CAS No.: 153107-67-6
• Molecular Formula: C₁₅H₁₉Cl₂FO₂S
• Molecular Weight: 353.285
• Mol file: 153107-67-6.mol

Synonyms:1-[(S)-(R)-3,3-Dichloro-3-fluoro-2-(3-methyl-but-2-enyloxy)-propane-1-sulfinyl]-4-methyl-benzene

Chemical Property of 1-[(S)-(R)-3,3-Dichloro-3-fluoro-2-(3-methyl-but-2-enyloxy)-propane-1-sulfinyl]-4-methyl-benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-[(S)-(R)-3,3-Dichloro-3-fluoro-2-(3-methyl-but-2-enyloxy)-propane-1-sulfinyl]-4-methyl-benzene

There total 1 articles about 1-[(S)-(R)-3,3-Dichloro-3-fluoro-2-(3-methyl-but-2-enyloxy)-propane-1-sulfinyl]-4-methyl-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

(2R,SS)-1,1-Dichloro-1-fluoro-3-<(4-methylphenyl)sulfinyl>propan-2-ol (132164-18-2) + prenyl bromide (870-63-3) → 1-[(S)-(R)-3,3-Dichloro-3-fluoro-2-(3-methyl-but-2-enyloxy)-propane-1-sulfinyl]-4-methyl-benzene (153107-67-6)

Guidance literature:

With sodium hydroxide; trioctylethyl-ammonium bromide; In dichloromethane; Ambient temperature;

DOI:10.1016/S0040-4020(01)85741-0

Reference yield: 1.0%

1-[(S)-(R)-3,3-Dichloro-3-fluoro-2-(3-methyl-but-2-enyloxy)-propane-1-sulfinyl]-4-methyl-benzene (153107-67-6) → (R)-3-Chloro-3-fluoro-4-isopropyl-2-((S)-toluene-4-sulfinylmethyl)-tetrahydro-furan

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; at 75 ℃; for 93h;

DOI:10.1016/S0040-4020(01)85741-0

Reference yield:

1-[(S)-(R)-3,3-Dichloro-3-fluoro-2-(3-methyl-but-2-enyloxy)-propane-1-sulfinyl]-4-methyl-benzene (153107-67-6) → (2S,3S,4S)-3-Fluoro-4-isopropyl-2-((S)-toluene-4-sulfinylmethyl)-tetrahydro-furan + (2S,3R,4S)-3-Fluoro-4-isopropyl-2-((S)-toluene-4-sulfinylmethyl)-tetrahydro-furan + (2S,3S,4R)-3-Fluoro-4-isopropyl-2-((S)-toluene-4-sulfinylmethyl)-tetrahydro-furan + (2S,3R,4R)-3-Fluoro-4-isopropyl-2-((S)-toluene-4-sulfinylmethyl)-tetrahydro-furan

Guidance literature:

With 2,2'-azobis(isobutyronitrile); tri-n-butyl-tin hydride; In benzene; at 75 ℃; for 12h; Yield given. Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1016/S0040-4020(01)85741-0

upstream raw materials:

(2R,S_S)-1,1-Dichloro-1-fluoro-3-<(4-methylphenyl)sulfinyl>propan-2-ol

prenyl bromide