2-furan-2-yl-7-[3-(4-nitro-phenyl)-propyl]-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine

Base Information

• Chemical Name: 2-furan-2-yl-7-[3-(4-nitro-phenyl)-propyl]-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine
• CAS No.: 396124-18-8
• Molecular Formula: C₁₉H₁₆N₈O₃
• Molecular Weight: 404.388

Synonyms:2-furan-2-yl-7-[3-(4-nitro-phenyl)-propyl]-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine

Chemical Property of 2-furan-2-yl-7-[3-(4-nitro-phenyl)-propyl]-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine

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Technology Process of 2-furan-2-yl-7-[3-(4-nitro-phenyl)-propyl]-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine

There total 2 articles about 2-furan-2-yl-7-[3-(4-nitro-phenyl)-propyl]-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

3-(4-nitrophenyl)propyl chloride (20264-93-1) + 2-furan-2-yl-7H-pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidin-5-yl amine (162401-16-3,321661-12-5) → 2-furan-2-yl-7-[3-(4-nitro-phenyl)-propyl]-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine (396124-18-8)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃;

DOI:10.1021/jm010924c

Reference yield:

phenylpropyl chloride (104-52-9) → 2-furan-2-yl-7-[3-(4-nitro-phenyl)-propyl]-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine (396124-18-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / 90 percent HNO₃ / 0.33 h / 0 °C

2: 56 percent / K₂CO₃ / dimethylformamide / 100 °C

With nitric acid; potassium carbonate; In N,N-dimethyl-formamide;

DOI:10.1021/jm010924c

Reference yield: 100.0%

2-furan-2-yl-7-[3-(4-nitro-phenyl)-propyl]-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine (396124-18-8) → 7-[3-(4-amino-phenyl)-propyl]-2-furan-2-yl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-ylamine

Guidance literature:

With hydrazine hydrate; 10percent Pd/C; In 1,4-dioxane; for 0.75h; Heating;

DOI:10.1021/jm010924c

upstream raw materials:

3-(4-nitrophenyl)propyl chloride

2-furan-2-yl-7H-pyrazolo[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidin-5-yl amine

phenylpropyl chloride

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