N-(2-FLUORO-PHENYL)-GUANIDINE HYDROCHLORIDE

Base Information

• Chemical Name: N-(2-FLUORO-PHENYL)-GUANIDINE HYDROCHLORIDE
• CAS No.: 1187927-51-0
• Molecular Formula: C₇H₈FN₃*ClH
• Molecular Weight: 189.62
• Mol file: 1187927-51-0.mol

Synonyms:1-(2-fluorophenyl)guanidine hydrochloride

Chemical Property of N-(2-FLUORO-PHENYL)-GUANIDINE HYDROCHLORIDE

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

N-(2-Fluoro-phenyl)-guanidinehydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-FLUORO-PHENYL)-GUANIDINE HYDROCHLORIDE

There total 2 articles about N-(2-FLUORO-PHENYL)-GUANIDINE HYDROCHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

2-[(2-fluorophenyl)amino]-4,6-dimethoxypyrimidine (1627898-14-9) → 1-(2-fluorophenyl)guanidine hydrochloride (1187927-51-0)

Guidance literature:

With hydrogenchloride; In water; acetic acid; at 100 ℃; for 10h;

DOI:10.1002/ejoc.201402179

Reference yield:

o-fluorobromobenzene (1072-85-1) → 1-(2-fluorophenyl)guanidine hydrochloride (1187927-51-0)

Guidance literature:

Multi-step reaction with 2 steps

1: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate / toluene / 95 °C / Schlenk technique; Inert atmosphere

2: hydrogenchloride / water; acetic acid / 10 h / 100 °C

With hydrogenchloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; sodium t-butanolate; In water; acetic acid; toluene; 1: |Buchwald-Hartwig Coupling;

DOI:10.1002/ejoc.201402179

upstream raw materials:

o-fluorobromobenzene

2-[(2-fluorophenyl)amino]-4,6-dimethoxypyrimidine

Refernces