N-[4-(3-aminophenyl)-3-cyano-6-(2-hydroxyphenyl)-pyridin-2-yl]thiophene-2-carboxamide

Base Information

Chemical Name:N-[4-(3-aminophenyl)-3-cyano-6-(2-hydroxyphenyl)-pyridin-2-yl]thiophene-2-carboxamide
CAS No.:712350-29-3
Molecular Formula:C₂₃H₁₆N₄O₂S
Molecular Weight:412.472
Hs Code.:

Synonyms:N-[4-(3-aminophenyl)-3-cyano-6-(2-hydroxyphenyl)-pyridin-2-yl]thiophene-2-carboxamide

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Chemical Property of N-[4-(3-aminophenyl)-3-cyano-6-(2-hydroxyphenyl)-pyridin-2-yl]thiophene-2-carboxamide

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Technology Process of N-[4-(3-aminophenyl)-3-cyano-6-(2-hydroxyphenyl)-pyridin-2-yl]thiophene-2-carboxamide

There total 3 articles about N-[4-(3-aminophenyl)-3-cyano-6-(2-hydroxyphenyl)-pyridin-2-yl]thiophene-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 30.0%

: 712350-28-2
N-[3-cyano-6-(2-hydroxyphenyl)-4-(3-nitrophenyl)-2-pyridinyl]thiophene-2-carboxamide

: 712350-29-3
N-[4-(3-aminophenyl)-3-cyano-6-(2-hydroxyphenyl)-pyridin-2-yl]thiophene-2-carboxamide

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In ethanol; isopropyl alcohol; under 2250.23 Torr; Product distribution / selectivity;

Reference yield: 17.0%

: 925921-62-6
N-[4-(3-aminophenyl)-6-(2-{[tert-butyl(dimethyl)silyl]-oxy}phenyl)-3-cyanopyridin-2-yl]thiophene-2-carboxamide

: 712350-29-3
N-[4-(3-aminophenyl)-3-cyano-6-(2-hydroxyphenyl)-pyridin-2-yl]thiophene-2-carboxamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 0.666667h;
DOI:10.1016/j.bmc.2010.04.036

Reference yield: 10.0%

: 712350-28-2
N-[3-cyano-6-(2-hydroxyphenyl)-4-(3-nitrophenyl)-2-pyridinyl]thiophene-2-carboxamide

: 712350-29-3
N-[4-(3-aminophenyl)-3-cyano-6-(2-hydroxyphenyl)-pyridin-2-yl]thiophene-2-carboxamide

: 433958-64-6
2-amino-4-(3-aminophenyl)-6-(2-hydroxyphenyl)nicotinonitrile

Guidance literature:: N-[3-cyano-6-(2-hydroxyphenyl)-4-(3-nitrophenyl)-2-pyridinyl]thiophene-2-carboxamide; With bismuth(III) chloride; sodium tetrahydroborate; In ethanol; at 20 ℃;

With hydrogenchloride; water; In ethanol; for 1h;

With ammonia; In water; Product distribution / selectivity;