2-[(4-chloro-benzylidene)-amino]-2-methyl-pentanedioic acid 1-tert-butyl ester 5-methyl ester

Base Information

Chemical Name:2-[(4-chloro-benzylidene)-amino]-2-methyl-pentanedioic acid 1-tert-butyl ester 5-methyl ester
CAS No.:882392-19-0
Molecular Formula:C₁₈H₂₄ClNO₄
Molecular Weight:353.846
Hs Code.:

2-[(4-chloro-benzylidene)-amino]-2-methyl-pentanedioic acid 1-<i>tert</i>-butyl ester 5-methyl ester

Synonyms:2-[(4-chloro-benzylidene)-amino]-2-methyl-pentanedioic acid 1-tert-butyl ester 5-methyl ester

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Chemical Property of 2-[(4-chloro-benzylidene)-amino]-2-methyl-pentanedioic acid 1-tert-butyl ester 5-methyl ester

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Technology Process of 2-[(4-chloro-benzylidene)-amino]-2-methyl-pentanedioic acid 1-tert-butyl ester 5-methyl ester

There total 1 articles about 2-[(4-chloro-benzylidene)-amino]-2-methyl-pentanedioic acid 1-tert-butyl ester 5-methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 292638-85-8,9003-21-8,96-33-3
acrylic acid methyl ester

: tert-butyl 2-[(E)-(4-chlorophenyl)methyleneamino]propanoate

: 882392-19-0
2-[(4-chloro-benzylidene)-amino]-2-methyl-pentanedioic acid 1-tert-butyl ester 5-methyl ester

: 2-[(4-chloro-benzylidene)-amino]-2-methyl-pentanedioic acid 1-tert-butyl ester 5-methyl ester

Guidance literature:: With cesium hydroxide; chiral phase-transfer catalyst; In various solvent(s); at -60 ℃; for 61h; Title compound not separated from byproducts;
DOI:10.3987/COM-05-S(T)41

Reference yield:

: 882392-19-0
2-[(4-chloro-benzylidene)-amino]-2-methyl-pentanedioic acid 1-tert-butyl ester 5-methyl ester

: 42856-71-3
(S)-2-methylpyrrolidine-2-carboxylic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: aq. citric acid / tetrahydrofuran / 45 h / 20 °C

2.1: DMAP / acetonitrile / 5 h / 20 °C

3.1: DIBAL / toluene / 2 h / -78 °C

3.2: BF₃*Et₂O; Et₃SiH / CH₂Cl₂ / 2 h / -78 °C

4.1: aq. HCl / tetrahydrofuran / 1 h / Heating

4.2: propylene oxide / tetrahydrofuran; ethanol / 0.5 h / Heating

With hydrogenchloride; dmap; diisobutylaluminium hydride; citric acid; In tetrahydrofuran; toluene; acetonitrile;
DOI:10.3987/COM-05-S(T)41