7-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-3-(3-chlorophenyl)-2-methylisoquinolin-1(2H)-one

Base Information

Chemical Name:7-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-3-(3-chlorophenyl)-2-methylisoquinolin-1(2H)-one
CAS No.:1290636-49-5
Molecular Formula:C₂₃H₂₄ClN₃O
Molecular Weight:393.916
Hs Code.:

Synonyms:7-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-3-(3-chlorophenyl)-2-methylisoquinolin-1(2H)-one

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Chemical Property of 7-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-3-(3-chlorophenyl)-2-methylisoquinolin-1(2H)-one

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Technology Process of 7-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-3-(3-chlorophenyl)-2-methylisoquinolin-1(2H)-one

There total 4 articles about 7-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-3-(3-chlorophenyl)-2-methylisoquinolin-1(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1290634-41-1
7-bromo-3-(3-chlorophenyl)-2-methylisoquinolin-1(2H)-one

: 283-38-5
1,4-diazabicyclo[3.2.2]nonane

: 1290636-49-5
7-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-3-(3-chlorophenyl)-2-methylisoquinolin-1(2H)-one

Guidance literature:: With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; at 85 ℃; Inert atmosphere; Sealed vessel;

Reference yield:

: 1290634-40-0
7-bromo-3-(3-chlorophenyl)isoquinolin-1(2H)-one

: 1290636-49-5
7-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-3-(3-chlorophenyl)-2-methylisoquinolin-1(2H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / tetrahydrofuran / 0.5 h / Inert atmosphere

1.2: 20 °C / Cooling with ice

2.1: sodium t-butanolate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 85 °C / Inert atmosphere; Sealed vessel

With sodium hydride; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; 1,4-dioxane;

Reference yield:

: 79669-49-1
5-bromo-2-methylbenzoic acid

: 1290636-49-5
7-(1,4-diazabicyclo[3.2.2]nonan-4-yl)-3-(3-chlorophenyl)-2-methylisoquinolin-1(2H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 2 °C / Inert atmosphere

2.1: lithium diisopropyl amide / tetrahydrofuran / 2.5 h / -78 - 78 °C

3.1: sodium hydride / tetrahydrofuran / 0.5 h / Inert atmosphere

3.2: 20 °C / Cooling with ice

4.1: sodium t-butanolate / 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾ / 1,4-dioxane / 85 °C / Inert atmosphere; Sealed vessel

With sodium hydride; N-ethyl-N,N-diisopropylamine; sodium t-butanolate; lithium diisopropyl amide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In tetrahydrofuran; 1,4-dioxane; dichloromethane;