2'-fluoro-5'-[8-fluoro-7-(1-methyl-1-triethylsilanyloxy-ethyl)-imidazo[1,2-a]pyridin-3-yl]-biphenyl-2-carbonitrile

Base Information

Chemical Name:2'-fluoro-5'-[8-fluoro-7-(1-methyl-1-triethylsilanyloxy-ethyl)-imidazo[1,2-a]pyridin-3-yl]-biphenyl-2-carbonitrile
CAS No.:882187-82-8
Molecular Formula:C₂₉H₃₁F₂N₃OSi
Molecular Weight:503.667
Hs Code.:

2'-fluoro-5'-[8-fluoro-7-(1-methyl-1-triethylsilanyloxy-ethyl)-imidazo[1,2-<i>a</i>]pyridin-3-yl]-biphenyl-2-carbonitrile

Synonyms:2'-fluoro-5'-[8-fluoro-7-(1-methyl-1-triethylsilanyloxy-ethyl)-imidazo[1,2-a]pyridin-3-yl]-biphenyl-2-carbonitrile

Suppliers and Price of 2'-fluoro-5'-[8-fluoro-7-(1-methyl-1-triethylsilanyloxy-ethyl)-imidazo[1,2-a]pyridin-3-yl]-biphenyl-2-carbonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2'-fluoro-5'-[8-fluoro-7-(1-methyl-1-triethylsilanyloxy-ethyl)-imidazo[1,2-a]pyridin-3-yl]-biphenyl-2-carbonitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 2'-fluoro-5'-[8-fluoro-7-(1-methyl-1-triethylsilanyloxy-ethyl)-imidazo[1,2-a]pyridin-3-yl]-biphenyl-2-carbonitrile

There total 7 articles about 2'-fluoro-5'-[8-fluoro-7-(1-methyl-1-triethylsilanyloxy-ethyl)-imidazo[1,2-a]pyridin-3-yl]-biphenyl-2-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: 425378-72-9
2'-fluoro-5'-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)biphenyl-2-carbonitrile

: 628323-00-2
3-bromo-8-fluoro-7-[2-(triethylsilyloxy)prop-2-yl]imidazo[1,2-a]pyridine

: 882187-82-8
2'-fluoro-5'-[8-fluoro-7-(1-methyl-1-triethylsilanyloxy-ethyl)-imidazo[1,2-a]pyridin-3-yl]-biphenyl-2-carbonitrile

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In tetrahydrofuran; at 75 ℃;
DOI:10.1016/j.bmcl.2005.12.037

Reference yield:

: 2-(2-amino-3-fluoro-pyridin-4-yl)-propan-2-ol

: 882187-82-8
2'-fluoro-5'-[8-fluoro-7-(1-methyl-1-triethylsilanyloxy-ethyl)-imidazo[1,2-a]pyridin-3-yl]-biphenyl-2-carbonitrile

Guidance literature:: Multi-step reaction with 4 steps

1: propan-2-ol / 50 °C

2: 69 percent / Br₂; KBr; NaOAc / methanol

3: 83 percent / iPr₂NEt / CH₂Cl₂ / -78 - 20 °C

4: 60 percent / Pd(PPh₃)4; aq. Na₂CO₃ / tetrahydrofuran / 75 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; sodium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; potassium bromide; In tetrahydrofuran; methanol; dichloromethane; isopropyl alcohol; 4: Suzuki coupling;
DOI:10.1016/j.bmcl.2005.12.037

Reference yield:

: 628322-91-8
2-(8-fluoroimidazo[1,2-a]pyridin-7-yl)propan-2-ol

: 882187-82-8
2'-fluoro-5'-[8-fluoro-7-(1-methyl-1-triethylsilanyloxy-ethyl)-imidazo[1,2-a]pyridin-3-yl]-biphenyl-2-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 69 percent / Br₂; KBr; NaOAc / methanol

2: 83 percent / iPr₂NEt / CH₂Cl₂ / -78 - 20 °C

3: 60 percent / Pd(PPh₃)4; aq. Na₂CO₃ / tetrahydrofuran / 75 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; bromine; sodium acetate; sodium carbonate; N-ethyl-N,N-diisopropylamine; potassium bromide; In tetrahydrofuran; methanol; dichloromethane; 3: Suzuki coupling;
DOI:10.1016/j.bmcl.2005.12.037