4-((7-([1,1'-biphenyl]-2-ylamino)benzo[c][1,2,5]oxadiazol-4-yl)amino)-4-oxobutanoic acid

Base Information

Chemical Name:4-((7-([1,1'-biphenyl]-2-ylamino)benzo[c][1,2,5]oxadiazol-4-yl)amino)-4-oxobutanoic acid
CAS No.:1416316-24-9
Molecular Formula:C₂₂H₁₈N₄O₄
Molecular Weight:402.409
Hs Code.:

Synonyms:4-((7-([1,1'-biphenyl]-2-ylamino)benzo[c][1,2,5]oxadiazol-4-yl)amino)-4-oxobutanoic acid

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Chemical Property of 4-((7-([1,1'-biphenyl]-2-ylamino)benzo[c][1,2,5]oxadiazol-4-yl)amino)-4-oxobutanoic acid

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Technology Process of 4-((7-([1,1'-biphenyl]-2-ylamino)benzo[c][1,2,5]oxadiazol-4-yl)amino)-4-oxobutanoic acid

There total 4 articles about 4-((7-([1,1'-biphenyl]-2-ylamino)benzo[c][1,2,5]oxadiazol-4-yl)amino)-4-oxobutanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 1416316-21-6
N-4-[(1,1'-biphenyl)-2-yl]benzo[c][1,2,5]oxadiazole-4,7-diamine

: 4938-01-6
succinic acid monochloride

: 1416316-24-9
4-((7-([1,1'-biphenyl]-2-ylamino)benzo[c][1,2,5]oxadiazol-4-yl)amino)-4-oxobutanoic acid

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 16h;
DOI:10.1016/j.bmcl.2012.10.013

Reference yield:

: 90-41-5
2-phenylaniline

: 1416316-24-9
4-((7-([1,1'-biphenyl]-2-ylamino)benzo[c][1,2,5]oxadiazol-4-yl)amino)-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: tertiary amine / acetonitrile / 16 h / Reflux; Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol; tetrahydrofuran / 16 h / 20 °C

3: triethylamine / dichloromethane / 16 h / 0 - 20 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2012.10.013

Reference yield:

: 10199-89-0
NBD chloride

: 1416316-24-9
4-((7-([1,1'-biphenyl]-2-ylamino)benzo[c][1,2,5]oxadiazol-4-yl)amino)-4-oxobutanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: tertiary amine / acetonitrile / 16 h / Reflux; Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / methanol; tetrahydrofuran / 16 h / 20 °C

3: triethylamine / dichloromethane / 16 h / 0 - 20 °C

With palladium 10% on activated carbon; hydrogen; triethylamine; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1016/j.bmcl.2012.10.013