1-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3-[(4-[1,2,4]triazol-1-ylmethyl-phenylimino)-methyl]-1H-quinolin-2-one

Base Information

Chemical Name:1-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3-[(4-[1,2,4]triazol-1-ylmethyl-phenylimino)-methyl]-1H-quinolin-2-one
CAS No.:1599479-43-2
Molecular Formula:C₃₃H₂₅N₉O
Molecular Weight:563.621
Hs Code.:

Synonyms:1-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3-[(4-[1,2,4]triazol-1-ylmethyl-phenylimino)-methyl]-1H-quinolin-2-one

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Chemical Property of 1-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3-[(4-[1,2,4]triazol-1-ylmethyl-phenylimino)-methyl]-1H-quinolin-2-one

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Technology Process of 1-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3-[(4-[1,2,4]triazol-1-ylmethyl-phenylimino)-methyl]-1H-quinolin-2-one

There total 12 articles about 1-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3-[(4-[1,2,4]triazol-1-ylmethyl-phenylimino)-methyl]-1H-quinolin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.3%

: C₂₄H₁₇N₅O₂

: 119192-10-8
4-(1H-1,2,4-triazol-1-ylmethyl)aniline

: 1599479-43-2
1-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3-[(4-[1,2,4]triazol-1-ylmethyl-phenylimino)-methyl]-1H-quinolin-2-one

Guidance literature:: In methanol; Reflux;
DOI:10.1007/s12039-013-0541-4

Reference yield:

: C₅₂H₃₉N₉O

: 1599479-43-2
1-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3-[(4-[1,2,4]triazol-1-ylmethyl-phenylimino)-methyl]-1H-quinolin-2-one

Guidance literature:: With hydrogenchloride; water; Reflux;
DOI:10.1007/s12039-013-0541-4

Reference yield:

: 5720-05-8
4-methylphenylboronic acid

: 1599479-43-2
1-[2'-(1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-3-[(4-[1,2,4]triazol-1-ylmethyl-phenylimino)-methyl]-1H-quinolin-2-one

Guidance literature:: Multi-step reaction with 7 steps

1: palladium diacetate; triethylamine; triphenylphosphine / acetonitrile

2: sodium azide / N,N-dimethyl-formamide

3: potassium hydroxide / methanol

4: bromine; acetic acid

5: potassium carbonate / N,N-dimethyl-formamide / 20 °C

6: potassium hydroxide; water / methanol / 2 h / Reflux

7: methanol / Reflux

With sodium azide; water; bromine; palladium diacetate; potassium carbonate; acetic acid; triethylamine; triphenylphosphine; potassium hydroxide; In methanol; N,N-dimethyl-formamide; acetonitrile; 1: |Suzuki Coupling;
DOI:10.1007/s12039-013-0541-4