S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-(2-diisopropylamino-acetyl)sulfoximide

Base Information

Chemical Name:S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-(2-diisopropylamino-acetyl)sulfoximide
CAS No.:1147095-88-2
Molecular Formula:C₂₈H₃₁Cl₂N₅O₄S
Molecular Weight:604.557
Hs Code.:

Synonyms:S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-(2-diisopropylamino-acetyl)sulfoximide

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Chemical Property of S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-(2-diisopropylamino-acetyl)sulfoximide

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Technology Process of S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-(2-diisopropylamino-acetyl)sulfoximide

There total 12 articles about S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-(2-diisopropylamino-acetyl)sulfoximide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1147095-62-2,1147096-65-8
5-chloro-2-(4-(N-(2-chloroacetyl)-S-methylsulfonimidoyl)benzamido)-N-(5-chloropyridin-2-yl)benzamide

: 108-18-9
diisopropylamine

: 1147095-88-2
S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-(2-diisopropylamino-acetyl)sulfoximide

Guidance literature:: With potassium iodide; In N,N-dimethyl-formamide; at 25 - 30 ℃; for 12h;
DOI:10.1016/j.ejmech.2012.10.005

Reference yield: 86.0%

: 1147095-88-2
S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-(2-diisopropylamino-acetyl)sulfoximide

Guidance literature:

Reference yield:

: 114129-35-0
methyl 4-(methylsulfinyl)benzoate

: 1147095-88-2
S-[4-(N-{2-[N-(5-chloro(2-pyridyl))carbamoyl]-4-chlorophenyl}carbamoyl)phenyl]-S-methyl-N-(2-diisopropylamino-acetyl)sulfoximide

Guidance literature:: Multi-step reaction with 8 steps

1: sodium azide; sulfuric acid / chloroform / 15 h / -20 - 50 °C / Inert atmosphere

2: pyridine / dichloromethane; toluene / 3 h / 15 - 30 °C / Inert atmosphere

3: water; sodium hydroxide / tetrahydrofuran / 3 h / 25 - 30 °C

4: N,N-dimethyl-formamide; oxalyl dichloride / dichloromethane / 3 h / 10 - 30 °C / Inert atmosphere

5: tetrahydrofuran / 2 h / 10 - 30 °C / Inert atmosphere

6: sulfuric acid / 0 - 5 °C

7: triethylamine / tetrahydrofuran / 2 h / 0 - 30 °C

8: potassium iodide / N,N-dimethyl-formamide / 12 h / 25 - 30 °C

With pyridine; sodium azide; oxalyl dichloride; sulfuric acid; water; triethylamine; N,N-dimethyl-formamide; potassium iodide; sodium hydroxide; In tetrahydrofuran; dichloromethane; chloroform; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.ejmech.2012.10.005