methyl 2-(tert-butyldimethylsilyloxy)-6-(3-chloroprop-1-ynyl)cyclohex-1-enecarboxylate

Base Information

• Chemical Name: methyl 2-(tert-butyldimethylsilyloxy)-6-(3-chloroprop-1-ynyl)cyclohex-1-enecarboxylate
• CAS No.: 1042163-10-9
• Molecular Formula: C₁₇H₂₇ClO₃Si
• Molecular Weight: 342.938
• Mol file: 1042163-10-9.mol

Synonyms:methyl 2-(tert-butyldimethylsilyloxy)-6-(3-chloroprop-1-ynyl)cyclohex-1-enecarboxylate

Chemical Property of methyl 2-(tert-butyldimethylsilyloxy)-6-(3-chloroprop-1-ynyl)cyclohex-1-enecarboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(tert-butyldimethylsilyloxy)-6-(3-chloroprop-1-ynyl)cyclohex-1-enecarboxylate

There total 1 articles about methyl 2-(tert-butyldimethylsilyloxy)-6-(3-chloroprop-1-ynyl)cyclohex-1-enecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

t-butyldimethylsiyl triflate (69739-34-0) + 2-carbomethoxy-2-cyclohexenone (52784-37-9) + 2-propynyl chloride (624-65-7) → methyl 2-(tert-butyldimethylsilyloxy)-6-(3-chloroprop-1-ynyl)cyclohex-1-enecarboxylate (1042163-10-9)

Guidance literature:

2-propynyl chloride; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.75h;

With trimethylaluminum; In tetrahydrofuran; hexane; at -78 ℃; for 1h;

t-butyldimethylsiyl triflate; 2-carbomethoxy-2-cyclohexenone; In tetrahydrofuran; hexane; at -78 ℃;

DOI:10.1021/ja803553a

Reference yield: 85.0%

methyl 2-(tert-butyldimethylsilyloxy)-6-(3-chloroprop-1-ynyl)cyclohex-1-enecarboxylate (1042163-10-9) → methyl 2-(tert-butyldimethylsilyloxy)-6-(3-iodoprop-1-ynyl)cyclohex-1-enecarboxylate (1042163-18-7)

Guidance literature:

With sodium iodide; In acetone; at 60 ℃; for 3.5h;

DOI:10.1021/ja803553a

upstream raw materials:

t-butyldimethylsiyl triflate

2-carbomethoxy-2-cyclohexenone

2-propynyl chloride

Downstream raw materials:

methyl 2-(tert-butyldimethylsilyloxy)-6-(3-iodoprop-1-ynyl)cyclohex-1-enecarboxylate