(2S,4R)-5-(2'-fluorobiphenyl-4-yl)-2-hydroxymethyl-4-[(1-hydroxy-1H-[1,2,3]triazole-4-carbonyl)amino]-2-methylpentanoic acid

Base Information

Chemical Name:(2S,4R)-5-(2'-fluorobiphenyl-4-yl)-2-hydroxymethyl-4-[(1-hydroxy-1H-[1,2,3]triazole-4-carbonyl)amino]-2-methylpentanoic acid
CAS No.:1394050-05-5
Molecular Formula:C₂₂H₂₃FN₄O₅
Molecular Weight:442.447
Hs Code.:

Synonyms:(2S,4R)-5-(2'-fluorobiphenyl-4-yl)-2-hydroxymethyl-4-[(1-hydroxy-1H-[1,2,3]triazole-4-carbonyl)amino]-2-methylpentanoic acid

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Chemical Property of (2S,4R)-5-(2'-fluorobiphenyl-4-yl)-2-hydroxymethyl-4-[(1-hydroxy-1H-[1,2,3]triazole-4-carbonyl)amino]-2-methylpentanoic acid

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Technology Process of (2S,4R)-5-(2'-fluorobiphenyl-4-yl)-2-hydroxymethyl-4-[(1-hydroxy-1H-[1,2,3]triazole-4-carbonyl)amino]-2-methylpentanoic acid

There total 9 articles about (2S,4R)-5-(2'-fluorobiphenyl-4-yl)-2-hydroxymethyl-4-[(1-hydroxy-1H-[1,2,3]triazole-4-carbonyl)amino]-2-methylpentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1562404-83-4
(2S,4R)-4-amino-5-(2'-fluorobiphenyl-4-yl)-2-hydroxymethyl-2-methylpentanoic acid

: 134051-02-8
1-hydroxy-1H-[1,2,3]-triazole-4-carboxylic acid

: 1394050-05-5
(2S,4R)-5-(2'-fluorobiphenyl-4-yl)-2-hydroxymethyl-4-[(1-hydroxy-1H-[1,2,3]triazole-4-carbonyl)amino]-2-methylpentanoic acid

Guidance literature:: 1-hydroxy-1H-[1,2,3]-triazole-4-carboxylic acid; With N-ethyl-N,N-diisopropylamine; HATU; In N,N-dimethyl-formamide; at 23 ℃; for 0.0833333h;

(2S,4R)-4-amino-5-(2'-fluorobiphenyl-4-yl)-2-hydroxymethyl-2-methylpentanoic acid; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 0.25h;

Reference yield:

: 1383027-95-9
C₂₀H₂₄BrNO₇

: 1394050-05-5
(2S,4R)-5-(2'-fluorobiphenyl-4-yl)-2-hydroxymethyl-4-[(1-hydroxy-1H-[1,2,3]triazole-4-carbonyl)amino]-2-methylpentanoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid / dichloromethane / 0.5 h / -5 °C / Inert atmosphere

1.2: 3.5 h / -5 - 23 °C

2.1: potassium carbonate / N,N-dimethyl-formamide / 0 - 23 °C

3.1: palladium bis[bis(diphenylphosphino)ferrocene] dichloride; potassium fluoride / water; 1,4-dioxane / 2 h / 60 °C / Inert atmosphere

4.1: water; samarium; iodine / tetrahydrofuran / 2.5 h / -70 - 23 °C / Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

6.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.08 h / 23 °C

6.2: 0.25 h

With potassium fluoride; samarium; palladium bis[bis(diphenylphosphino)ferrocene] dichloride; water; iodine; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;

Reference yield:

: 1562404-97-0
C₂₇H₃₂FNO₆

: 1394050-05-5
(2S,4R)-5-(2'-fluorobiphenyl-4-yl)-2-hydroxymethyl-4-[(1-hydroxy-1H-[1,2,3]triazole-4-carbonyl)amino]-2-methylpentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; samarium; iodine / tetrahydrofuran / 2.5 h / -70 - 23 °C / Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide

3.1: HATU; N-ethyl-N,N-diisopropylamine / N,N-dimethyl-formamide / 0.08 h / 23 °C

3.2: 0.25 h

With samarium; water; iodine; N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; N,N-dimethyl-formamide;