inositol 1,2,3-trisphosphate

Base Information

• Chemical Name: inositol 1,2,3-trisphosphate
• CAS No.: 41613-02-9
• Molecular Formula: C6H15O15P3
• Molecular Weight: 420.097
• Mol file: 41613-02-9.mol

Synonyms:myo-inositol 1,2,3-trisphosphate;myo-Inositol 1,2,3-triphosphate;(+/-)-myo-inositol 1,2,3-trisphosphate;myo-inositol-1,2,3.-trisphosphate;D-myo-inositol-1,2,3-triphosphate;Phosphoric acid mono-((1R,2S,3S,4R,5S,6S)-2,3,4-trihydroxy-5,6-bis-phosphonooxy-cyclohexyl) ester;myo-inositol 1,2,3-tris(dihydrogen phosphate);

Chemical Property of inositol 1,2,3-trisphosphate

Chemical Property:

• Vapor Pressure: 1.04E-32mmHg at 25°C
• Boiling Point: 839.2°Cat760mmHg
• Flash Point: 461.3°C
• PSA: 290.40000
• Density: 2.25g/cm³
• LogP: -3.48360

Purity/Quality:

99% ^*data from raw suppliers

D-myo-Inositol 1,2,3-triphosphate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of inositol 1,2,3-trisphosphate

There total 10 articles about inositol 1,2,3-trisphosphate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

4,5,6-tri-O-benzyl-myo-inositol 1,2,3-tris(dibenzyl phosphate) (890318-11-3) → Inositol 1,2,3-triphosphate (41613-02-9,1311140-98-3)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; water; at 20 ℃; for 12h;

DOI:10.1016/j.carres.2006.02.029

Reference yield: 99.0%

D-myo-inositol 1,2,3,4-tetrakisphosphate (114418-90-5) → Inositol 1,2,3-triphosphate (41613-02-9,1311140-98-3)

Guidance literature:

With InsP₄-phosphohydrolase; In water; at 22 ℃; pH=5.1;

DOI:10.1016/S0957-4166(00)00063-X

Reference yield:

4,6-di-O-benzyl-2-O-tert-butyldimethylsilyl-1,3-O-methylene-myo-inositol (890124-53-5) → Inositol 1,2,3-triphosphate (41613-02-9,1311140-98-3)

Guidance literature:

Multi-step reaction with 4 steps

1.1: 70 percent / sodium hydride; tetrabutylammonium iodide / dimethylformamide / 1 h / 20 °C

2.1: 93 percent / aq. HCl / methanol / 3 h / Heating

3.1: 1-H-tetrazole / acetonitrile; CH₂Cl₂ / 4 h / 20 °C

3.2: 90 percent / m-chloroperbenzoic acid / CH₂Cl₂; acetonitrile / 4 h / 0 °C

4.1: 100 percent / H₂ / Pd/C / methanol; H₂O / 12 h / 20 °C

With 1H-tetrazole; hydrogenchloride; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydride; palladium on activated charcoal; In methanol; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1016/j.carres.2006.02.029

upstream raw materials:

D-myo-inositol 1,2,3,4-tetrakisphosphate

4,5,6-tri-O-benzyl-myo-inositol 1,2,3-tris(dibenzyl phosphate)

4,6-di-O-benzyl-2-O-tert-butyldimethylsilyl-1,3-O-methylene-myo-inositol

4,5,6-tri-O-benzyl-DL-myo-inositol

Refernces

• 1、 Sala, Martin,Kolar, Jana,Strlic, Matija,Kocevar, Marijan. "Synthesis of myo-inositol 1,2,3-tris- and 1,2,3,5-tetrakis(dihydrogen phosphate)s as a tool for the inhibition of iron-gall-ink corrosion". . p. 897 - 902. Retrieved 2007/10/03.
• 2、 Nakano, Tadao,Joh, Toshio,Narita, Kazumasa,Hayakawa, Toshiro. "The pathway of dephosphorylation of myo-inositol hexakisphosphate by phytases from wheat bran of Triticum aestivum L. cv. Nourin #61". . p. 995 - 1003. Retrieved 2007/10/03.