(R)-5-Methyl-3-((S)-1-phenyl-ethylcarbamoyl)-hexanoic acid methyl ester

Base Information

• Chemical Name: (R)-5-Methyl-3-((S)-1-phenyl-ethylcarbamoyl)-hexanoic acid methyl ester
• CAS No.: 171347-91-4
• Molecular Formula: C₁₇H₂₅NO₃
• Molecular Weight: 291.39
• Mol file: 171347-91-4.mol

Synonyms:(R)-5-Methyl-3-((S)-1-phenyl-ethylcarbamoyl)-hexanoic acid methyl ester

Chemical Property of (R)-5-Methyl-3-((S)-1-phenyl-ethylcarbamoyl)-hexanoic acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-5-Methyl-3-((S)-1-phenyl-ethylcarbamoyl)-hexanoic acid methyl ester

There total 3 articles about (R)-5-Methyl-3-((S)-1-phenyl-ethylcarbamoyl)-hexanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

(S)-1-phenyl-ethylamine (2627-86-3) + D,L-2-isobutyl-3-(methoxycarbonyl)-propanoic acid (132631-36-8) → (R)-5-Methyl-3-((S)-1-phenyl-ethylcarbamoyl)-hexanoic acid methyl ester (171347-91-4)

Guidance literature:

In diethyl ether; for 24h; Ambient temperature;

DOI:10.1021/jm970494j

Reference yield:

2-methyl-2-propen-1-yl succinic anhydride (18908-20-8) → (R)-5-Methyl-3-((S)-1-phenyl-ethylcarbamoyl)-hexanoic acid methyl ester (171347-91-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 97.6 percent / H₂ / 10percent Pd/C / toluene / 14 h / 60 - 70 °C / 3102.9 Torr

2: 55.9 percent / 192 h / Ambient temperature

3: 64 percent / diethyl ether / 24 h / Ambient temperature

With hydrogen; palladium on activated charcoal; In diethyl ether; toluene;

DOI:10.1021/jm970494j

Reference yield:

dihydro-3-(RS)-(2-methylpropyl)-2,5-furandione (14035-83-7) → (R)-5-Methyl-3-((S)-1-phenyl-ethylcarbamoyl)-hexanoic acid methyl ester (171347-91-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 55.9 percent / 192 h / Ambient temperature

2: 64 percent / diethyl ether / 24 h / Ambient temperature

In diethyl ether;

DOI:10.1021/jm970494j

upstream raw materials:

(S)-1-phenyl-ethylamine

D,L-2-isobutyl-3-(methoxycarbonyl)-propanoic acid

2-methyl-2-propen-1-yl succinic anhydride

dihydro-3-(RS)-(2-methylpropyl)-2,5-furandione

Downstream raw materials:

(2R)-2-[(methoxycarbonyl)methyl]-4-methylpentanoic acid

galardin

(R)-3-[(S)-1-(2-Benzyloxycarbonylamino-ethylcarbamoyl)-2-(1H-indol-3-yl)-ethylcarbamoyl]-5-methyl-hexanoic acid methyl ester

(R)-3-[(S)-2-Biphenyl-4-yl-1-(3-morpholin-4-yl-propylcarbamoyl)-ethylcarbamoyl]-5-methyl-hexanoic acid methyl ester