1-[1-(5-chloro-2-nitro-phenyl)-piperidin-4-yl]-1H-benzoimidazol-2-ylamine

Base Information

Chemical Name:1-[1-(5-chloro-2-nitro-phenyl)-piperidin-4-yl]-1H-benzoimidazol-2-ylamine
CAS No.:1352721-64-2
Molecular Formula:C₁₈H₁₈ClN₅O₂
Molecular Weight:371.826
Hs Code.:

Synonyms:1-[1-(5-chloro-2-nitro-phenyl)-piperidin-4-yl]-1H-benzoimidazol-2-ylamine

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Chemical Property of 1-[1-(5-chloro-2-nitro-phenyl)-piperidin-4-yl]-1H-benzoimidazol-2-ylamine

Chemical Property:

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Technology Process of 1-[1-(5-chloro-2-nitro-phenyl)-piperidin-4-yl]-1H-benzoimidazol-2-ylamine

There total 3 articles about 1-[1-(5-chloro-2-nitro-phenyl)-piperidin-4-yl]-1H-benzoimidazol-2-ylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 88915-43-9
4-(2-amino-benzoimidazol-1-yl)-piperidine-1-carboxylic acid tert-butyl ester

: 700-37-8
4-chloro-2-fluoro-nitrobenzene

: 1352721-64-2
1-[1-(5-chloro-2-nitro-phenyl)-piperidin-4-yl]-1H-benzoimidazol-2-ylamine

Guidance literature:: 4-(2-amino-benzoimidazol-1-yl)-piperidine-1-carboxylic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 1.25h;

4-chloro-2-fluoro-nitrobenzene; With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 5.5h;

Reference yield:

: 87120-73-8
tert‐butyl 4‐((2‐nitrophenyl)amino)piperidine‐1‐carboxylate

: 1352721-64-2
1-[1-(5-chloro-2-nitro-phenyl)-piperidin-4-yl]-1H-benzoimidazol-2-ylamine

Guidance literature:: Multi-step reaction with 3 steps

1.1: hydrogen / palladium 10% on activated carbon / methanol / 2 h / 20 °C / 760.05 Torr

2.1: water / acetonitrile / 22 h / 20 °C

3.1: trifluoroacetic acid / dichloromethane / 1.25 h / 20 °C

3.2: 5.5 h / 20 °C

With water; hydrogen; trifluoroacetic acid; palladium 10% on activated carbon; In methanol; dichloromethane; acetonitrile;

Reference yield:

: 79099-00-6
tert‐butyl 4‐((2‐aminophenyl)amino)piperidine‐1‐carboxylate

: 1352721-64-2
1-[1-(5-chloro-2-nitro-phenyl)-piperidin-4-yl]-1H-benzoimidazol-2-ylamine

Guidance literature:: Multi-step reaction with 2 steps

1.1: water / acetonitrile / 22 h / 20 °C

2.1: trifluoroacetic acid / dichloromethane / 1.25 h / 20 °C

2.2: 5.5 h / 20 °C

With water; trifluoroacetic acid; In dichloromethane; acetonitrile;