7H-Pyrrolo(2,3-d)pyrimidine-5-carbonitrile, 4-amino-7-(3-deoxy-beta-D-erythro-pentofuranosyl)-

Base Information

Chemical Name:7H-Pyrrolo(2,3-d)pyrimidine-5-carbonitrile, 4-amino-7-(3-deoxy-beta-D-erythro-pentofuranosyl)-
CAS No.:105582-76-1
Molecular Formula:C₁₂H₁₃N₅O₃
Molecular Weight:275.267
Hs Code.:
DSSTox Substance ID:DTXSID80147205
Nikkaji Number:J373.006I
Wikidata:Q83012429

Synonyms:3'-Deoxytoyocamycin;BRN 6229674;7H-Pyrrolo(2,3-d)pyrimidine-5-carbonitrile, 4-amino-7-(3-deoxy-beta-D-erythro-pentofuranosyl)-;4-Amino-7-(3-deoxy-beta-D-erythro-pentofuranosyl)-7H-pyrrolo(2,3-d)pyrimidine-5-carbonitrile;105582-76-1;SCHEMBL1738494;DTXSID80147205;LS-139546;4-Amino-7-(3-hydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile;4-amino-7-[(2R,3R,5S)-3-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]pyrrolo[2,3-d]pyrimidine-5-carbonitrile

Suppliers and Price of 7H-Pyrrolo(2,3-d)pyrimidine-5-carbonitrile, 4-amino-7-(3-deoxy-beta-D-erythro-pentofuranosyl)-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 7H-Pyrrolo(2,3-d)pyrimidine-5-carbonitrile, 4-amino-7-(3-deoxy-beta-D-erythro-pentofuranosyl)-

Chemical Property:

Vapor Pressure:3.95E-19mmHg at 25°C
Boiling Point:674.8°C at 760 mmHg
Flash Point:361.9°C
Density:1.77g/cm³
XLogP3:-1.2
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:2
Exact Mass:275.10183929
Heavy Atom Count:20
Complexity:413

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1C(OC(C1O)N2C=C(C3=C(N=CN=C32)N)C#N)CO
Isomeric SMILES:C1[C@H](O[C@H]([C@@H]1O)N2C=C(C3=C(N=CN=C32)N)C#N)CO

Technology Process of 7H-Pyrrolo(2,3-d)pyrimidine-5-carbonitrile, 4-amino-7-(3-deoxy-beta-D-erythro-pentofuranosyl)-

There total 3 articles about 7H-Pyrrolo(2,3-d)pyrimidine-5-carbonitrile, 4-amino-7-(3-deoxy-beta-D-erythro-pentofuranosyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 606-58-6
Vengicide

: 105582-76-1
3'-deoxytoyocamycin

Guidance literature:: Multi-step reaction with 3 steps

1: acetonitrile / 6.5 h / Ambient temperature

2: Et₃N / methanol / 24 h / 0 °C

3: 1.) H₂, Et₃N, 2.) NH₃ / 1.) 5 percent Pd/C / 1.) EtOH, RT, 48 h, 2.) MeOH, RT, 36 h

With ammonia; hydrogen; triethylamine; palladium on activated charcoal; In methanol; acetonitrile;
DOI:10.1021/jm00386a007

Reference yield:

: 105582-77-2
2-Acetoxy-2-methyl-propionic acid (2R,3S,4S,5R)-4-acetoxy-5-(4-amino-5-cyano-pyrrolo[2,3-d]pyrimidin-7-yl)-3-bromo-tetrahydro-furan-2-ylmethyl ester

: 105582-76-1
3'-deoxytoyocamycin

Guidance literature:: Multi-step reaction with 2 steps

1: Et₃N / methanol / 24 h / 0 °C

2: 1.) H₂, Et₃N, 2.) NH₃ / 1.) 5 percent Pd/C / 1.) EtOH, RT, 48 h, 2.) MeOH, RT, 36 h

With ammonia; hydrogen; triethylamine; palladium on activated charcoal; In methanol;
DOI:10.1021/jm00386a007

Reference yield:

: 105582-78-3
2-Acetoxy-2-methyl-propionic acid (2R,3R,4S,5R)-5-(4-amino-5-cyano-pyrrolo[2,3-d]pyrimidin-7-yl)-3-bromo-4-hydroxy-tetrahydro-furan-2-ylmethyl ester

: 83379-31-1
3'-Deoxysangivamycin

: 105582-76-1
3'-deoxytoyocamycin

Guidance literature:: With ammonia; hydrogen; triethylamine; palladium on activated charcoal; Yield given. Multistep reaction. Yields of byproduct given; 1.) EtOH, RT, 48 h, 2.) MeOH, RT, 36 h;
DOI:10.1021/jm00386a007