7-Benzyloxy-1-<4-<3-(2-methyl-1,3-dioxolan-2-yl)>pyridylmethyl>-6-methoxyisochinolin

Base Information

• Chemical Name: 7-Benzyloxy-1-<4-<3-(2-methyl-1,3-dioxolan-2-yl)>pyridylmethyl>-6-methoxyisochinolin
• CAS No.: 162150-41-6
• Molecular Formula: C₂₇H₂₆N₂O₄
• Molecular Weight: 442.514
• Mol file: 162150-41-6.mol

Synonyms:7-Benzyloxy-1-<4-<3-(2-methyl-1,3-dioxolan-2-yl)>pyridylmethyl>-6-methoxyisochinolin

Chemical Property of 7-Benzyloxy-1-<4-<3-(2-methyl-1,3-dioxolan-2-yl)>pyridylmethyl>-6-methoxyisochinolin

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-Benzyloxy-1-<4-<3-(2-methyl-1,3-dioxolan-2-yl)>pyridylmethyl>-6-methoxyisochinolin

There total 4 articles about 7-Benzyloxy-1-<4-<3-(2-methyl-1,3-dioxolan-2-yl)>pyridylmethyl>-6-methoxyisochinolin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

2-benzoyl-7-benzyloxy-1,2-dihydro-6-methoxyisoquinoline-1-carbonitrile (107588-82-9) + 3-Acetyl-4-chlormethylpyridin-dioxolan (162150-35-8) → 7-Benzyloxy-1-<4-<3-(2-methyl-1,3-dioxolan-2-yl)>pyridylmethyl>-6-methoxyisochinolin (162150-41-6)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; at 0 ℃; for 3.5h;

DOI:10.1007/BF00811089

Reference yield:

3-Acetyl-4-methylpyridindioxolan-1-oxid (162150-33-6) → 7-Benzyloxy-1-<4-<3-(2-methyl-1,3-dioxolan-2-yl)>pyridylmethyl>-6-methoxyisochinolin (162150-41-6)

Guidance literature:

Multi-step reaction with 2 steps

1: p-TsCl / dioxane / 1 h / Heating

2: 71 percent / 80percent NaH / dimethylformamide / 3.5 h / 0 °C

With sodium hydride; p-toluenesulfonyl chloride; In 1,4-dioxane; N,N-dimethyl-formamide;

DOI:10.1007/BF00811089

Reference yield:

3-Acetyl-4-methylpyridin-hydrochlorid (24476-58-2) → 7-Benzyloxy-1-<4-<3-(2-methyl-1,3-dioxolan-2-yl)>pyridylmethyl>-6-methoxyisochinolin (162150-41-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 96 percent / pyridinium toluene-4-sulfonate / benzene / 40 h / Heating

2: 30percent H₂O₂ / acetic acid / 8 h / 80 °C

3: p-TsCl / dioxane / 1 h / Heating

4: 71 percent / 80percent NaH / dimethylformamide / 3.5 h / 0 °C

With dihydrogen peroxide; pyridinium p-toluenesulfonate; sodium hydride; p-toluenesulfonyl chloride; In 1,4-dioxane; acetic acid; N,N-dimethyl-formamide; benzene;

DOI:10.1007/BF00811089

upstream raw materials:

2-benzoyl-7-benzyloxy-1,2-dihydro-6-methoxyisoquinoline-1-carbonitrile

3-Acetyl-4-chlormethylpyridin-dioxolan

3-Acetyl-4-methylpyridindioxolan-1-oxid

3-Acetyl-4-methylpyridin-hydrochlorid

Refernces