(2R,3R)-3-azido-4-tert-butyldiphenylsilyloxy-1,2-O-isopropylidenebutane-1,2-diol

Base Information

Chemical Name:(2R,3R)-3-azido-4-tert-butyldiphenylsilyloxy-1,2-O-isopropylidenebutane-1,2-diol
CAS No.:201933-48-4
Molecular Formula:C₂₃H₃₁N₃O₃Si
Molecular Weight:425.603
Hs Code.:

Synonyms:(2R,3R)-3-azido-4-tert-butyldiphenylsilyloxy-1,2-O-isopropylidenebutane-1,2-diol

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Chemical Property of (2R,3R)-3-azido-4-tert-butyldiphenylsilyloxy-1,2-O-isopropylidenebutane-1,2-diol

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Technology Process of (2R,3R)-3-azido-4-tert-butyldiphenylsilyloxy-1,2-O-isopropylidenebutane-1,2-diol

There total 5 articles about (2R,3R)-3-azido-4-tert-butyldiphenylsilyloxy-1,2-O-isopropylidenebutane-1,2-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 183888-74-6
(S)-4-{(1S)-2-[(1,1-dimethylethyl)diphenylsilyloxy]-1-(hydroxy)ethyl}-2,2-dimethyl-1,3-dioxolane

: 201933-48-4
(2R,3R)-3-azido-4-tert-butyldiphenylsilyloxy-1,2-O-isopropylidenebutane-1,2-diol

Guidance literature:: (S)-4-{(1S)-2-[(1,1-dimethylethyl)diphenylsilyloxy]-1-(hydroxy)ethyl}-2,2-dimethyl-1,3-dioxolane; With 2,6-dimethylpyridine; trifluoromethylsulfonic anhydride; In dichloromethane; at -78 ℃;

With sodium azide; In N,N-dimethyl-formamide; at 0 - 20 ℃; Further stages.;
DOI:10.1016/j.tetlet.2007.09.098

Reference yield: 81.0%

: Trifluoro-methanesulfonic acid (S)-2-(tert-butyl-diphenyl-silanyloxy)-1-((S)-2,2-dimethyl-[1,3]dioxolan-4-yl)-ethyl ester

: 201933-48-4
(2R,3R)-3-azido-4-tert-butyldiphenylsilyloxy-1,2-O-isopropylidenebutane-1,2-diol

Guidance literature:: With tetramethylguanidinum azide; In dichloromethane; at -78 - 20 ℃;
DOI:10.1002/1099-0690(200108)2001:16<3089::AID-EJOC3089>3.0.CO;2-L

Reference yield:

: 91274-05-4
(2S,3S)-1,2-O-isopropylidene-1,2,3,4-tetrol

: 201933-48-4
(2R,3R)-3-azido-4-tert-butyldiphenylsilyloxy-1,2-O-isopropylidenebutane-1,2-diol

Guidance literature:: Multi-step reaction with 3 steps

1: 97 percent / imidazole / dimethylformamide / -10 °C

2: 100 percent / 2,6-lutidine / CH₂Cl₂ / 0.5 h / -78 °C

3: 81 percent / tetramethylguanidinium azide / CH₂Cl₂ / -78 - 20 °C

With 1H-imidazole; 2,6-dimethylpyridine; tetramethylguanidinum azide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1002/1099-0690(200108)2001:16<3089::AID-EJOC3089>3.0.CO;2-L