4-methyl-3-[[4-(3-pyridyl)-2-pyrimidinyl]amino]benzoyl chloride

Base Information

• Chemical Name: 4-methyl-3-[[4-(3-pyridyl)-2-pyrimidinyl]amino]benzoyl chloride
• CAS No.: 1205540-17-5
• Molecular Formula: C₁₇H₁₃ClN₄O
• Molecular Weight: 324.769
• Mol file: 1205540-17-5.mol

Synonyms:4-methyl-3-[[4-(3-pyridyl)-2-pyrimidinyl]amino]benzoyl chloride

Chemical Property of 4-methyl-3-[[4-(3-pyridyl)-2-pyrimidinyl]amino]benzoyl chloride

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 4-methyl-3-[[4-(3-pyridyl)-2-pyrimidinyl]amino]benzoyl chloride

There total 12 articles about 4-methyl-3-[[4-(3-pyridyl)-2-pyrimidinyl]amino]benzoyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-amino-4-methylbenzoic acid ethyl ester (41191-92-8) → 4-methyl-3-[[4-(3-pyridyl)-2-pyrimidinyl]amino]benzoyl chloride (1205540-17-5)

Guidance literature:

Multi-step reaction with 5 steps

1: hydrogenchloride / ethanol; water / 15 h / Reflux

2: ammonium nitrate / 0.5 h / 0 °C

3: sodium hydroxide / butan-1-ol / 72 h / Reflux; Inert atmosphere

4: sodium hydroxide / ethanol; water / 4 h / 45 - 50 °C

5: thionyl chloride / N,N-dimethyl-formamide / 1.5 h / Reflux

With ammonium nitrate; hydrogenchloride; thionyl chloride; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide; butan-1-ol;

DOI:10.1111/cbdd.12272

Reference yield:

4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid (641569-94-0) → 4-methyl-3-[[4-(3-pyridyl)-2-pyrimidinyl]amino]benzoyl chloride (1205540-17-5)

Guidance literature:

With thionyl chloride; In toluene; at 50 ℃; for 2h; Product distribution / selectivity; Inert atmosphere;

Reference yield:

4-methyl-3-[[4-(3-pyridyl)-2-pyrimidinyl]amino]benzoic acid ethyl ester (641569-97-3) → 4-methyl-3-[[4-(3-pyridyl)-2-pyrimidinyl]amino]benzoyl chloride (1205540-17-5)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol; water / 4 h / 45 - 50 °C

2: thionyl chloride / N,N-dimethyl-formamide / 1.5 h / Reflux

With thionyl chloride; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide;

DOI:10.1111/cbdd.12272

upstream raw materials:

4-methyl-3-{[4-(pyridin-3-yl)pyrimidin-2-yl]amino}benzoic acid

3-amino-p-toluic acid

3-amino-4-methylbenzoic acid ethyl ester

3-guanidino-4-methylbenzoic acid ethyl ester nitrate

Downstream raw materials:

4-methyl-3-((4-(pyridin-3-yl)pyrimidin-2-yl)amino)-N-(3-(trifluoromethyl)phenyl)benzamide