2-methyl-1-(4-chlorophenyl)-5-(2-oxopropyl)-4,5,6,7-tetrahydro-1H-4-indolone

Base Information

Chemical Name:2-methyl-1-(4-chlorophenyl)-5-(2-oxopropyl)-4,5,6,7-tetrahydro-1H-4-indolone
CAS No.:1026490-26-5
Molecular Formula:C₁₈H₁₈ClNO₂
Molecular Weight:315.799
Hs Code.:

Synonyms:2-methyl-1-(4-chlorophenyl)-5-(2-oxopropyl)-4,5,6,7-tetrahydro-1H-4-indolone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 2-methyl-1-(4-chlorophenyl)-5-(2-oxopropyl)-4,5,6,7-tetrahydro-1H-4-indolone

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Technology Process of 2-methyl-1-(4-chlorophenyl)-5-(2-oxopropyl)-4,5,6,7-tetrahydro-1H-4-indolone

There total 4 articles about 2-methyl-1-(4-chlorophenyl)-5-(2-oxopropyl)-4,5,6,7-tetrahydro-1H-4-indolone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1027154-08-0
5-allyl-2-methyl-1-(4-chlorophenyl)-4,5,6,7-tetrahydro-1H-4-indolone

: 1026490-26-5
2-methyl-1-(4-chlorophenyl)-5-(2-oxopropyl)-4,5,6,7-tetrahydro-1H-4-indolone

Guidance literature:: With oxygen; copper(l) chloride; palladium dichloride; In N,N-dimethyl-formamide; for 22h; Ambient temperature;
DOI:10.1002/jhet.5570350315

Reference yield:

: 90534-62-6
2-(2-oxopropyl)cyclohexane-1,3-dione

: 1026490-26-5
2-methyl-1-(4-chlorophenyl)-5-(2-oxopropyl)-4,5,6,7-tetrahydro-1H-4-indolone

Guidance literature:: Multi-step reaction with 3 steps

1: 32 percent / glacial acetic acid / 18 h / Heating

2: 1.) LDA / 1.) THF, -78 deg C, 20 min, 2.) THF, -78 deg C, 1 h

3: 89 percent / O₂, aq. CuCl, PdCl₂ / dimethylformamide / 22 h / Ambient temperature

With oxygen; acetic acid; copper(l) chloride; palladium dichloride; lithium diisopropyl amide; In N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570350315

Reference yield:

: 106-47-8
4-chloro-aniline

: 1026490-26-5
2-methyl-1-(4-chlorophenyl)-5-(2-oxopropyl)-4,5,6,7-tetrahydro-1H-4-indolone

Guidance literature:: Multi-step reaction with 3 steps

1: 32 percent / glacial acetic acid / 18 h / Heating

2: 1.) LDA / 1.) THF, -78 deg C, 20 min, 2.) THF, -78 deg C, 1 h

3: 89 percent / O₂, aq. CuCl, PdCl₂ / dimethylformamide / 22 h / Ambient temperature

With oxygen; acetic acid; copper(l) chloride; palladium dichloride; lithium diisopropyl amide; In N,N-dimethyl-formamide;
DOI:10.1002/jhet.5570350315