Technology Process of (2S,3S)-2,3-epoxy-1-(4-methoxybenzyl)oxy-4-phenylbutane
There total 2 articles about (2S,3S)-2,3-epoxy-1-(4-methoxybenzyl)oxy-4-phenylbutane which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
sodium hydride;
In
tetrahydrofuran; N,N-dimethyl-formamide;
for 20h;
Ambient temperature;
DOI:10.1248/cpb.46.1816
- Guidance literature:
-
Multi-step reaction with 2 steps
1: titanium isopropoxide, diethyl L-tartrate, tert-butyl hydroperoxide, 4A molecular sieves / CH2Cl2 / 4 h / -20 °C
2: 97 percent / NaH / tetrahydrofuran; dimethylformamide / 20 h / Ambient temperature
With
titanium(IV) isopropylate; tert.-butylhydroperoxide; diethyl (2R,3R)-tartrate; 4 A molecular sieve; sodium hydride;
In
tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1248/cpb.46.1816
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 1.) n-butyllithium / 1.) hexane, toluene, -20 deg C, 2.) hexane, toluene, -20 deg C, 24 h
2: 93 percent / Et3N / CH2Cl2 / 6 h / 0 °C
3: 97 percent / DDQ / CH2Cl2; H2O / 3.5 h / Ambient temperature
4: 96 percent / K2CO3 / methanol / 5 h / 0 - 20 °C
5: 1.) BF3*OEt2 / 1.) THF, hexane, -78 deg C, 15 min, 2.) THF, hexane, -78 deg C, 0.5 h
With
n-butyllithium; boron trifluoride diethyl etherate; potassium carbonate; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
methanol; dichloromethane; water;
DOI:10.1248/cpb.46.1816
