1-(2',3'-dideoxy-5-O-(4-methylbenzoyl)-α-D-glycero-pentofuranosyl)-5-pentoxymethylcytosine

Base Information

Chemical Name:1-(2',3'-dideoxy-5-O-(4-methylbenzoyl)-α-D-glycero-pentofuranosyl)-5-pentoxymethylcytosine
CAS No.:133635-70-8
Molecular Formula:C₂₃H₃₁N₃O₅
Molecular Weight:429.516
Hs Code.:

Synonyms:1-(2',3'-dideoxy-5-O-(4-methylbenzoyl)-α-D-glycero-pentofuranosyl)-5-pentoxymethylcytosine

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Chemical Property of 1-(2',3'-dideoxy-5-O-(4-methylbenzoyl)-α-D-glycero-pentofuranosyl)-5-pentoxymethylcytosine

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Technology Process of 1-(2',3'-dideoxy-5-O-(4-methylbenzoyl)-α-D-glycero-pentofuranosyl)-5-pentoxymethylcytosine

There total 14 articles about 1-(2',3'-dideoxy-5-O-(4-methylbenzoyl)-α-D-glycero-pentofuranosyl)-5-pentoxymethylcytosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 34.0%

: 133635-66-2,133697-46-8
4-Methyl-benzoic acid (S)-5-(2-oxo-5-pentyloxymethyl-4-[1,2,4]triazol-1-yl-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

: 133635-70-8
1-(2',3'-dideoxy-5-O-(4-methylbenzoyl)-α-D-glycero-pentofuranosyl)-5-pentoxymethylcytosine

: 133635-70-8,133697-49-1
2',3'-dideoxy-5-O-(4-methylbenzoyl)-5-pentyloxymethylcytidine

Guidance literature:: With ammonium hydroxide; In 1,4-dioxane; Ambient temperature;
DOI:10.1007/BF00815166

Reference yield: 34.0%

: 133635-66-2,133697-46-8
4-Methyl-benzoic acid (S)-5-(2-oxo-5-pentyloxymethyl-4-[1,2,4]triazol-1-yl-2H-pyrimidin-1-yl)-tetrahydro-furan-2-ylmethyl ester

: 133635-70-8
1-(2',3'-dideoxy-5-O-(4-methylbenzoyl)-α-D-glycero-pentofuranosyl)-5-pentoxymethylcytosine

: 133635-70-8,133697-49-1
2',3'-dideoxy-5-O-(4-methylbenzoyl)-5-pentyloxymethylcytidine

Guidance literature:: With ammonium hydroxide; In 1,4-dioxane; Ambient temperature;
DOI:10.1007/BF00815166

Reference yield:

: 32780-06-6
(5S)-5-(hydroxymethyl)-2-oxo-tetrahydrofuran

: 133635-70-8
1-(2',3'-dideoxy-5-O-(4-methylbenzoyl)-α-D-glycero-pentofuranosyl)-5-pentoxymethylcytosine

Guidance literature:: Multi-step reaction with 6 steps

1: 42 percent / pyridine / a) r.t., 0.5h, b) 80 deg C, 3h

2: DIBAL / tetrahydrofuran; hexane / 0.5 h / -75 °C

3: 0.2 percent HCl / 0.25 h / Ambient temperature

4: trimethylsilyl triflate / CH₂Cl₂ / Ambient temperature

5: 89 percent / POCl₃, Et₃N / acetonitrile / Ambient temperature

6: 46 percent / 20percent aq.NH₃ / dioxane / Ambient temperature

With pyridine; hydrogenchloride; ammonium hydroxide; trimethylsilyl trifluoromethanesulfonate; diisobutylaluminium hydride; triethylamine; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; hexane; dichloromethane; acetonitrile;
DOI:10.1007/BF00815166