4-(2-(butylamino)-5-(4-fluorophenyl)-6,7-dihydro-5H-pyrrolo[3,2-d]pyrimidin-7-yl)cyclohexanol

Base Information

Chemical Name:4-(2-(butylamino)-5-(4-fluorophenyl)-6,7-dihydro-5H-pyrrolo[3,2-d]pyrimidin-7-yl)cyclohexanol
CAS No.:1429882-18-7
Molecular Formula:C₂₂H₂₉FN₄O
Molecular Weight:384.497
Hs Code.:

Synonyms:4-(2-(butylamino)-5-(4-fluorophenyl)-6,7-dihydro-5H-pyrrolo[3,2-d]pyrimidin-7-yl)cyclohexanol

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Chemical Property of 4-(2-(butylamino)-5-(4-fluorophenyl)-6,7-dihydro-5H-pyrrolo[3,2-d]pyrimidin-7-yl)cyclohexanol

Chemical Property:

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Technology Process of 4-(2-(butylamino)-5-(4-fluorophenyl)-6,7-dihydro-5H-pyrrolo[3,2-d]pyrimidin-7-yl)cyclohexanol

There total 6 articles about 4-(2-(butylamino)-5-(4-fluorophenyl)-6,7-dihydro-5H-pyrrolo[3,2-d]pyrimidin-7-yl)cyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1429882-35-8
4-(2-(butylamino)-5-(4-fluorophenyl)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)cyclohex-3-enol?

: cis-4-(2-(butylamino)-5-(4-fluorophenyl)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)cyclohexanol

: trans-4-(2-(butylamino)-5-(4-fluorophenyl)-5H-pyrrolo[3,2-d]pyrimidin-7-yl)cyclohexanol

: 1429882-18-7
4-(2-(butylamino)-5-(4-fluorophenyl)-6,7-dihydro-5H-pyrrolo[3,2-d]pyrimidin-7-yl)cyclohexanol

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; for 3h;

Reference yield:

: 1429882-31-4
N-butyl-5H-pyrrolo[3,2-d]pyrimidin-2-amine

: 1429882-18-7
4-(2-(butylamino)-5-(4-fluorophenyl)-6,7-dihydro-5H-pyrrolo[3,2-d]pyrimidin-7-yl)cyclohexanol

Guidance literature:: Multi-step reaction with 5 steps

1: potassium phosphate; copper(l) iodide; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane / N,N-dimethyl-formamide / 16 h / 110 °C / Inert atmosphere

2: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 20 °C

3: dipotassium phosphite; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 1 h / 150 °C

4: hydrogenchloride; water / ethanol / 16 h / 20 °C

5: palladium 10% on activated carbon; hydrogen / methanol / 3 h

With hydrogenchloride; potassium phosphate; dipotassium phosphite; N-Bromosuccinimide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; water; hydrogen; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane; In tetrahydrofuran; methanol; ethanol; N,N-dimethyl-formamide;

Reference yield:

: 1119280-66-8
2-chloro-5H-pyrrolo[3,2-d]pyrimidine?

: 1429882-18-7
4-(2-(butylamino)-5-(4-fluorophenyl)-6,7-dihydro-5H-pyrrolo[3,2-d]pyrimidin-7-yl)cyclohexanol

Guidance literature:: Multi-step reaction with 6 steps

1: hydrogenchloride / 1,4-dioxane; isopropyl alcohol / 1 h / 170 °C / Microwave irradiation

2: potassium phosphate; copper(l) iodide; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane / N,N-dimethyl-formamide / 16 h / 110 °C / Inert atmosphere

3: N-Bromosuccinimide / N,N-dimethyl-formamide / 1 h / 20 °C

4: dipotassium phosphite; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 1 h / 150 °C

5: hydrogenchloride; water / ethanol / 16 h / 20 °C

6: palladium 10% on activated carbon; hydrogen / methanol / 3 h

With hydrogenchloride; potassium phosphate; dipotassium phosphite; N-Bromosuccinimide; copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; palladium 10% on activated carbon; water; hydrogen; (1S,2S)-N,N'-dimethyl-1,2-diaminocyclohexane; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; N,N-dimethyl-formamide; isopropyl alcohol;