1N-(4-n-propoxybenzenesulfonyl)-2(R)-carbomethoxy-4(S)-(γ-sultam-1N-yl)pyrrolidine

Base Information

Chemical Name:1N-(4-n-propoxybenzenesulfonyl)-2(R)-carbomethoxy-4(S)-(γ-sultam-1N-yl)pyrrolidine
CAS No.:317860-19-8
Molecular Formula:C₁₈H₂₆N₂O₇S₂
Molecular Weight:446.546
Hs Code.:

Synonyms:1N-(4-n-propoxybenzenesulfonyl)-2(R)-carbomethoxy-4(S)-(γ-sultam-1N-yl)pyrrolidine

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Chemical Property of 1N-(4-n-propoxybenzenesulfonyl)-2(R)-carbomethoxy-4(S)-(γ-sultam-1N-yl)pyrrolidine

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Technology Process of 1N-(4-n-propoxybenzenesulfonyl)-2(R)-carbomethoxy-4(S)-(γ-sultam-1N-yl)pyrrolidine

There total 8 articles about 1N-(4-n-propoxybenzenesulfonyl)-2(R)-carbomethoxy-4(S)-(γ-sultam-1N-yl)pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 254881-77-1,1018667-18-9
1-tert-butyl 2-methyl (2R,4S)-4-aminopyrrolidine-1,2-dicarboxylate

: 317860-19-8
1N-(4-n-propoxybenzenesulfonyl)-2(R)-carbomethoxy-4(S)-(γ-sultam-1N-yl)pyrrolidine

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / Et₃N / CH₂Cl₂ / 18 h

2: 76 percent / DBU / dimethylformamide / 18 h

3: TFA / CH₂Cl₂ / 2 h

4: Et₃N / dioxane; H₂O / 16 h

With 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm000246e

Reference yield:

: 114676-69-6
(2R,4R)-1-tert-butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate

: 317860-19-8
1N-(4-n-propoxybenzenesulfonyl)-2(R)-carbomethoxy-4(S)-(γ-sultam-1N-yl)pyrrolidine

Guidance literature:: Multi-step reaction with 7 steps

1: Et₃N / CH₂Cl₂ / 20 °C

2: 59 percent / NaN₃ / dimethylformamide / 26 h / 55 °C

3: 61 percent / H₂; HCOOH / 10percent Pd/C / ethanol; tetrahydrofuran / 16 h / 2792.67 Torr

4: 98 percent / Et₃N / CH₂Cl₂ / 18 h

5: 76 percent / DBU / dimethylformamide / 18 h

6: TFA / CH₂Cl₂ / 2 h

7: Et₃N / dioxane; H₂O / 16 h

With formic acid; sodium azide; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; 10percent Pd/C; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/jm000246e

Reference yield:

: 114676-59-4
(2R,4R)-4-hydroxy-2-methoxycarbonylpyrrolidine hydrochloride

: 317860-19-8
1N-(4-n-propoxybenzenesulfonyl)-2(R)-carbomethoxy-4(S)-(γ-sultam-1N-yl)pyrrolidine

Guidance literature:: Multi-step reaction with 8 steps

1: Et₃N; DMAP / H₂O; acetone / 16 h

2: Et₃N / CH₂Cl₂ / 20 °C

3: 59 percent / NaN₃ / dimethylformamide / 26 h / 55 °C

4: 61 percent / H₂; HCOOH / 10percent Pd/C / ethanol; tetrahydrofuran / 16 h / 2792.67 Torr

5: 98 percent / Et₃N / CH₂Cl₂ / 18 h

6: 76 percent / DBU / dimethylformamide / 18 h

7: TFA / CH₂Cl₂ / 2 h

8: Et₃N / dioxane; H₂O / 16 h

With dmap; formic acid; sodium azide; hydrogen; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; trifluoroacetic acid; 10percent Pd/C; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1021/jm000246e