(R)-(-)-(4-hydroxy-6-oxo-1,6-dihydropyridin-2-yl)(phenyl)methyl3-methylbutanoate

Base Information

Chemical Name:(R)-(-)-(4-hydroxy-6-oxo-1,6-dihydropyridin-2-yl)(phenyl)methyl3-methylbutanoate
CAS No.:1303531-28-3
Molecular Formula:C₁₇H₁₉NO₄
Molecular Weight:301.342
Hs Code.:

Synonyms:(R)-(-)-(4-hydroxy-6-oxo-1,6-dihydropyridin-2-yl)(phenyl)methyl3-methylbutanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-(-)-(4-hydroxy-6-oxo-1,6-dihydropyridin-2-yl)(phenyl)methyl3-methylbutanoate

Chemical Property:

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Technology Process of (R)-(-)-(4-hydroxy-6-oxo-1,6-dihydropyridin-2-yl)(phenyl)methyl3-methylbutanoate

There total 4 articles about (R)-(-)-(4-hydroxy-6-oxo-1,6-dihydropyridin-2-yl)(phenyl)methyl3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 503-74-2
3-methylbutyric acid

: 1300040-40-7
(R)-4-hydroxy-6-(hydroxy(phenyl)methyl)pyridin-2(1H)-one

: 1303531-28-3
(R)-(-)-(4-hydroxy-6-oxo-1,6-dihydropyridin-2-yl)(phenyl)methyl3-methylbutanoate

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In methanol; dichloromethane; at 10 - 20 ℃; for 16h; regioselective reaction; Inert atmosphere;
DOI:10.1016/j.ejmech.2011.02.039

Reference yield:

: 1228555-59-6
C₁₉H₁₄ClNO₂

: 1303531-28-3
(R)-(-)-(4-hydroxy-6-oxo-1,6-dihydropyridin-2-yl)(phenyl)methyl3-methylbutanoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: water; acetic acid / 12 h / 180 - 190 °C / Sealed vessel

2.1: (+)-B-chlorodiisopinocampheylborane / tetrahydrofuran / 12 h / -40 - -10 °C / Inert atmosphere

2.2: Inert atmosphere; Cooling with ice

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / methanol; dichloromethane / 16 h / 10 - 20 °C / Inert atmosphere

With water; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; (+)-B-chlorodiisopinocampheylborane; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.ejmech.2011.02.039

Reference yield:

: 1228555-60-9
6-benzoyl-4-hydroxypyridin-2(1H)-one

: 1303531-28-3
(R)-(-)-(4-hydroxy-6-oxo-1,6-dihydropyridin-2-yl)(phenyl)methyl3-methylbutanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: (+)-B-chlorodiisopinocampheylborane / tetrahydrofuran / 12 h / -40 - -10 °C / Inert atmosphere

1.2: Inert atmosphere; Cooling with ice

2.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / methanol; dichloromethane / 16 h / 10 - 20 °C / Inert atmosphere

With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; (+)-B-chlorodiisopinocampheylborane; In tetrahydrofuran; methanol; dichloromethane;
DOI:10.1016/j.ejmech.2011.02.039