4-(2-bromo-4,5-dimethoxy-phenyl)-pentanoic acid methyl ester

Base Information

Chemical Name:4-(2-bromo-4,5-dimethoxy-phenyl)-pentanoic acid methyl ester
CAS No.:676562-89-3
Molecular Formula:C₁₄H₁₉BrO₄
Molecular Weight:331.206
Hs Code.:

Synonyms:4-(2-bromo-4,5-dimethoxy-phenyl)-pentanoic acid methyl ester

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Chemical Property of 4-(2-bromo-4,5-dimethoxy-phenyl)-pentanoic acid methyl ester

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Technology Process of 4-(2-bromo-4,5-dimethoxy-phenyl)-pentanoic acid methyl ester

There total 1 articles about 4-(2-bromo-4,5-dimethoxy-phenyl)-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 54.0%

: 2859-78-1
4-Bromoveratrole

: 77-78-1
dimethyl sulfate

: 108-29-2
5-methyl-dihydro-furan-2-one

: 676562-89-3
4-(2-bromo-4,5-dimethoxy-phenyl)-pentanoic acid methyl ester

Guidance literature:: 4-Bromoveratrole; 5-methyl-dihydro-furan-2-one; With aluminium trichloride; In 1,1,2,2-tetrachloroethane; at 70 ℃;

With acetyl chloride; In methanol; at 20 ℃; for 14h;

dimethyl sulfate; With potassium carbonate; In acetone; for 46h; Heating;
DOI:10.1246/cl.2004.136

Reference yield: 97.0%

: 676562-89-3
4-(2-bromo-4,5-dimethoxy-phenyl)-pentanoic acid methyl ester

: 676562-90-6
4-(2-bromo-4,5-dimethoxy-phenyl)-pentanoic acid

Guidance literature:: With sodium hydroxide; In methanol; at 40 ℃; for 24h;
DOI:10.1246/cl.2004.136

Reference yield:

: 676562-89-3
4-(2-bromo-4,5-dimethoxy-phenyl)-pentanoic acid methyl ester

: 676562-87-1
1-(4-bromo-1-methoxy-5-methyl-5,6,7,8-tetrahydro-naphthalen-2-yloxy)-propan-2-one

Guidance literature:: Multi-step reaction with 6 steps

1: 97 percent / NaOH / methanol / 24 h / 40 °C

2: 64 percent / (CF₃CO)2O / trifluoroacetic acid / 3 h / 40 °C

3: 98 percent / BBr₃ / CH₂Cl₂ / 18 h / -78 - -40 °C

4: 86 percent / Li₂CO₃ / 17 h / 70 °C

5: 77 percent / K₂CO₃ / acetone / 14 h / Heating

6: 52 percent / NaBH₄ / trifluoroacetic acid / 4 h / 0 - 20 °C

With sodium hydroxide; sodium tetrahydroborate; boron tribromide; lithium carbonate; potassium carbonate; trifluoroacetic anhydride; In methanol; dichloromethane; acetone; trifluoroacetic acid; 2: Friedel-Craft acylation;
DOI:10.1246/cl.2004.136