(S)-tert-butyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)propanoate

Base Information

• Chemical Name: (S)-tert-butyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)propanoate
• CAS No.: 33033-71-5
• Molecular Formula: C₂₄H₃₀N₂O₅
• Molecular Weight: 426.513
• Mol file: 33033-71-5.mol

Synonyms:(S)-tert-butyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)propanoate

Chemical Property of (S)-tert-butyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-tert-butyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)propanoate

There total 10 articles about (S)-tert-butyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

Nα-benzyloxycarbonyl-L-phenylalanine anhydride (14470-30-5) + tert-butyl L-alaninate hydrochloride (13404-22-3) → (S)-tert-butyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)propanoate (33033-71-5)

Guidance literature:

With triethylamine; In N,N-dimethyl-formamide; at -20 - 25 ℃; for 96h; or with LiCl;

DOI:10.1002/hlca.19910740319

Reference yield: 92.0%

Z-Phe-O-Pcp (3086-21-3) + tert-butyl L-alaninate hydrochloride (13404-22-3) → (S)-tert-butyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)propanoate (33033-71-5)

Guidance literature:

With 4-methyl-morpholine; lithium chloride; In N,N-dimethyl-formamide; at -40 - 25 ℃; for 18h; or with LiBF₄, or without salt;

DOI:10.1002/hlca.19910740319

Reference yield: 91.0%

N-benzyloxycarbonyl-L-phenylalanine p-nitrophenyl ester (2578-84-9) + tert-butyl L-alaninate hydrochloride (13404-22-3) → (S)-tert-butyl 2-((S)-2-(((benzyloxy)carbonyl)amino)-3-phenylpropanamido)propanoate (33033-71-5)

Guidance literature:

With 4-methyl-morpholine; lithium chloride; In tetrahydrofuran; at 25 ℃; for 24h; or without salt, or in DMF;

DOI:10.1002/hlca.19910740319

upstream raw materials:

Ala-OtBu

Cbz-Phe-OCH₂CONH₂

N-Cbz-L-Phe

tert-butyl L-alaninate hydrochloride

Downstream raw materials:

N-acetylglycyl-L-leucyl-3-chloro-L-alanyl-L-phenylalanyl-L-alanine tert-butyl ester

N-acetylglycyl-L-leucyl-3-chloro-L-alanyl-L-phenylalanyl-L-alanine

N-(benzyloxycarbonyl)-3-chloro-L-alanyl-L-phenylalanyl-L-alanine tert-butyl ester