(E)-1,4-dimethoxy-2,3,5-trimethyl-6-(3-methyl-4-(phenylsulfonyl)but-2-enyl)benzene

Base Information

Chemical Name:(E)-1,4-dimethoxy-2,3,5-trimethyl-6-(3-methyl-4-(phenylsulfonyl)but-2-enyl)benzene
CAS No.:73892-12-3
Molecular Formula:C₂₂H₂₈O₄S
Molecular Weight:388.528
Hs Code.:

Synonyms:(E)-1,4-dimethoxy-2,3,5-trimethyl-6-(3-methyl-4-(phenylsulfonyl)but-2-enyl)benzene

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-1,4-dimethoxy-2,3,5-trimethyl-6-(3-methyl-4-(phenylsulfonyl)but-2-enyl)benzene

Chemical Property:

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Technology Process of (E)-1,4-dimethoxy-2,3,5-trimethyl-6-(3-methyl-4-(phenylsulfonyl)but-2-enyl)benzene

There total 6 articles about (E)-1,4-dimethoxy-2,3,5-trimethyl-6-(3-methyl-4-(phenylsulfonyl)but-2-enyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₆H₂₃BrO₂

: 873-55-2
sodium benzenesulfonate

: 73892-12-3
(E)-1,4-dimethoxy-2,3,5-trimethyl-6-(3-methyl-4-(phenylsulfonyl)but-2-enyl)benzene

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 12h; Inert atmosphere;
DOI:10.3390/molecules25030448

Reference yield:

: 96203-92-8
(E)-4-(2,5-dimethoxy-3,4,6-trimethylcyclohexa-1,5-dienyl)-2-methylbut-2-en-1-ol

: 73892-12-3
(E)-1,4-dimethoxy-2,3,5-trimethyl-6-(3-methyl-4-(phenylsulfonyl)but-2-enyl)benzene

Guidance literature:: Multi-step reaction with 2 steps

1: phosphorus tribromide / tetrahydrofuran / 2.25 h / -5 °C

2: N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

With phosphorus tribromide; In tetrahydrofuran; N,N-dimethyl-formamide;
DOI:10.3390/molecules25030448

Reference yield:

: 69821-05-2
1-bromo-2,5-dimethoxy-3,4,6-trimethylbenzene

: 73892-12-3
(E)-1,4-dimethoxy-2,3,5-trimethyl-6-(3-methyl-4-(phenylsulfonyl)but-2-enyl)benzene

Guidance literature:: Multi-step reaction with 5 steps

1: bis-triphenylphosphine-palladium(II) chloride; triphenylphosphine / N,N-dimethyl-formamide / 4 h / 110 °C / Inert atmosphere

2: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 24 h / 40 °C / Inert atmosphere

3: lithium aluminium tetrahydride / diethyl ether; tetrahydrofuran / 4 h / 0 - 20 °C

4: phosphorus tribromide / tetrahydrofuran / 2.25 h / -5 °C

5: N,N-dimethyl-formamide / 12 h / 20 °C / Inert atmosphere

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; bis-triphenylphosphine-palladium(II) chloride; lithium aluminium tetrahydride; phosphorus tribromide; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; N,N-dimethyl-formamide; 1: |Stille Cross Coupling;
DOI:10.3390/molecules25030448