(RS)-2-(3-Phenyl-2-propenoyl)-oxy-2-phenylessigsaeuremethylester

Base Information

• Chemical Name: (RS)-2-(3-Phenyl-2-propenoyl)-oxy-2-phenylessigsaeuremethylester
• CAS No.: 124786-85-2
• Molecular Formula: C₁₈H₁₆O₄
• Molecular Weight: 296.323
• Mol file: 124786-85-2.mol

Synonyms:(RS)-2-(3-Phenyl-2-propenoyl)-oxy-2-phenylessigsaeuremethylester

Chemical Property of (RS)-2-(3-Phenyl-2-propenoyl)-oxy-2-phenylessigsaeuremethylester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of (RS)-2-(3-Phenyl-2-propenoyl)-oxy-2-phenylessigsaeuremethylester

There total 7 articles about (RS)-2-(3-Phenyl-2-propenoyl)-oxy-2-phenylessigsaeuremethylester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.1%

(E)-3-phenylacrylic acid (140-10-3) + (RS)-methyl mandelate (4358-87-6) → (RS)-2-(3-Phenyl-2-propenoyl)-oxy-2-phenylessigsaeuremethylester (124786-85-2)

Guidance literature:

With dicyclohexyl-carbodiimide; 4-pyrrolidin-1-ylpyridine; In dichloromethane; -10 to -5 deg C, 30 min then room temp.;

DOI:10.1002/ardp.19893220903

Reference yield: 83.0%

(E)-3-phenylacrylic acid (140-10-3) + Methyl phenyldiazoacetate (22979-35-7) → (RS)-2-(3-Phenyl-2-propenoyl)-oxy-2-phenylessigsaeuremethylester (124786-85-2)

Guidance literature:

With tris(pentafluorophenyl)borate; In dichloromethane; at 20 ℃; for 12h; Schlenk technique; Inert atmosphere; Sealed tube;

DOI:10.1002/adsc.201801389

Reference yield:

benzeneacetic acid methyl ester (101-41-7) → (RS)-2-(3-Phenyl-2-propenoyl)-oxy-2-phenylessigsaeuremethylester (124786-85-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 4-toluenesulfonyl azide / acetonitrile

2: tris(pentafluorophenyl)borate / dichloromethane / 12 h / 20 °C / Schlenk technique; Inert atmosphere; Sealed tube

With 4-toluenesulfonyl azide; tris(pentafluorophenyl)borate; In dichloromethane; acetonitrile;

DOI:10.1002/adsc.201801389

upstream raw materials:

(RS)-methyl mandelate

cinnamoyl chloride

(E)-3-phenylacrylic acid

Methyl phenyldiazoacetate