5-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-pentanoic acid (5,11-dihydro-10-thia-dibenzo[a,d]cyclohepten-5-yl)-amide

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Chemical Name:5-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-pentanoic acid (5,11-dihydro-10-thia-dibenzo[a,d]cyclohepten-5-yl)-amide
CAS No.:103377-51-1
Molecular Formula:C₂₉H₃₂FN₃OS
Molecular Weight:489.657
Hs Code.:

Synonyms:5-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-pentanoic acid (5,11-dihydro-10-thia-dibenzo[a,d]cyclohepten-5-yl)-amide

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Chemical Property of 5-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-pentanoic acid (5,11-dihydro-10-thia-dibenzo[a,d]cyclohepten-5-yl)-amide

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Technology Process of 5-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-pentanoic acid (5,11-dihydro-10-thia-dibenzo[a,d]cyclohepten-5-yl)-amide

There total 3 articles about 5-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-pentanoic acid (5,11-dihydro-10-thia-dibenzo[a,d]cyclohepten-5-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 103379-35-7
11-(5-chlorovalerylamino)-6,11-dihydrodibenzo[b,e]thiepin

: 2252-63-3
1-(4-Fluorophenyl)piperazine

: 103377-51-1
5-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-pentanoic acid (5,11-dihydro-10-thia-dibenzo[a,d]cyclohepten-5-yl)-amide

Guidance literature:: With sodium iodide; In N,N-dimethyl-formamide; at 80 ℃; for 3h;
DOI:10.1021/jm00107a009

Reference yield:

: 1745-53-5
11-amino-6,11-dihydrodibenzothiepin

: 103377-51-1
5-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-pentanoic acid (5,11-dihydro-10-thia-dibenzo[a,d]cyclohepten-5-yl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / toluene / 6 h / Heating

2: 70 percent / NaI / dimethylformamide / 3 h / 80 °C

With sodium iodide; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00107a009

Reference yield:

: 1575-61-7
5-Chlorovaleroyl chloride

: 103377-51-1
5-[4-(4-Fluoro-phenyl)-piperazin-1-yl]-pentanoic acid (5,11-dihydro-10-thia-dibenzo[a,d]cyclohepten-5-yl)-amide

Guidance literature:: Multi-step reaction with 2 steps

1: 80 percent / toluene / 6 h / Heating

2: 70 percent / NaI / dimethylformamide / 3 h / 80 °C

With sodium iodide; In N,N-dimethyl-formamide; toluene;
DOI:10.1021/jm00107a009