p-Nitrobenzyl 7-amino-3-hydroxy-3-cephem-4-carboxylate hydrochloride salt

Base Information

• Chemical Name: p-Nitrobenzyl 7-amino-3-hydroxy-3-cephem-4-carboxylate hydrochloride salt
• CAS No.: 53116-43-1
• Molecular Formula: C₁₄H₁₃N₃O₆S*ClH
• Molecular Weight: 387.801

Synonyms:p-Nitrobenzyl 7-amino-3-hydroxy-3-cephem-4-carboxylate hydrochloride salt

Chemical Property of p-Nitrobenzyl 7-amino-3-hydroxy-3-cephem-4-carboxylate hydrochloride salt

Chemical Property:

Purity/Quality:

95%+ or 98%+ ^*data from raw suppliers

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Technology Process of p-Nitrobenzyl 7-amino-3-hydroxy-3-cephem-4-carboxylate hydrochloride salt

There total 1 articles about p-Nitrobenzyl 7-amino-3-hydroxy-3-cephem-4-carboxylate hydrochloride salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ p-Nitrobenzyl 7-amino-3-hydroxy-3-cephem-4-carboxylate hydrochloride salt (53116-43-1)

Guidance literature:

Entspr. 3-Methylenverb. 1b, 1.) O3, 2.) SO2;

DOI:10.1021/ja00822a045

Reference yield:

(6R)-7t-amino-3,8-dioxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]octane-2ξ-carboxylic acid 4-nitro-benzyl ester; hydrochloride (53116-43-1) → (6R)-7t-amino-3-chloro-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester (53994-83-5)

Guidance literature:

Multi-step reaction with 3 steps

1: aq. NaHCO₃ / acetone

2: SOCl₂ / dimethylformamide

3: PCl₅, Py / CH₂Cl₂

With pyridine; thionyl chloride; phosphorus pentachloride; sodium hydrogencarbonate; In dichloromethane; N,N-dimethyl-formamide; acetone;

DOI:10.1021/ja00822a045

Reference yield:

p-Nitrobenzyl 7-amino-3-hydroxy-3-cephem-4-carboxylate hydrochloride salt (53116-43-1) → p-Nitrobenzyl 7β-[(dimethylaminomethylene)amino]-3-chloro-3-cephem-4-carboxylate

Guidance literature:

With anhydrous phosphorus trichloride; In diethyl ether; water; ethyl acetate; N,N-dimethyl-formamide;

Downstream raw materials:

(6R)-7t-amino-3-methoxy-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

(6R)-3,8-dioxo-7t-(2-thiophen-2-yl-acetylamino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]octane-2ξ-carboxylic acid 4-nitro-benzyl ester

(6R)-7t-((R)-2-hydroxy-2-phenyl-acetylamino)-3-methoxy-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

(6R)-7t-((R)-2-hydroxy-2-phenyl-acetylamino)-3-methoxy-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 4-nitro-benzyl ester

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