ethyl 6-methyl-4-(3-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-carboxylate

Base Information

• Chemical Name: ethyl 6-methyl-4-(3-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-carboxylate
• CAS No.: 914915-59-6
• Molecular Formula: C₁₄H₁₅N₃O₄S
• Molecular Weight: 321.357
• Mol file: 914915-59-6.mol

Synonyms:ethyl 6-methyl-4-(3-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-carboxylate

Chemical Property of ethyl 6-methyl-4-(3-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of ethyl 6-methyl-4-(3-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-carboxylate

There total 8 articles about ethyl 6-methyl-4-(3-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethyl acetoacetate (141-97-9) + 3-nitro-benzaldehyde (99-61-6) + thiourea (17356-08-0) → ethyl 6-methyl-4-(3-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-carboxylate (914915-59-6)

Guidance literature:

With citric acid; In ethanol; for 6h; Reflux; Green chemistry;

DOI:10.1002/jccs.201300118

Reference yield: 93.0%

thiouronium hydrogensulfate (37622-16-5) + ethyl acetoacetate (141-97-9) + 3-nitro-benzaldehyde (99-61-6) → ethyl 6-methyl-4-(3-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-carboxylate (914915-59-6)

Guidance literature:

With thiourea; at 65 ℃; for 3h;

DOI:10.3987/COM-04-10312

Reference yield: 62.0%

ethyl (Z)-2-(3-nitrobenzylidene)-3-oxobutanoate (39562-16-8) + thiourea (17356-08-0) → ethyl 6-methyl-4-(3-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidin-5-carboxylate (914915-59-6)

Guidance literature:

thiourea; With 1-methyl-pyrrolidin-2-one; resin bound 4-(benzyloxy)benzyl chloride; at 75 ℃; for 16h; solid phase reaction;

ethyl (Z)-2-(3-nitrobenzylidene)-3-oxobutanoate; With 1-methyl-pyrrolidin-2-one; caesium carbonate; at 90 ℃; for 16h; solid phase reaction;

With trifluoroacetic acid; ethanethiol; In dichloromethane; at 20 ℃; for 16h;

DOI:10.1016/S0960-894X(99)00572-7

upstream raw materials:

1,4-Dihydro-2-[[(4-methoxyphenyl)methyl]-thio]-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid,ethyl ester

ethyl acetoacetate

3-nitro-benzaldehyde

thiourea

Downstream raw materials:

2-[2-(Benzyl-methyl-amino)-ethylsulfanyl]-6-methyl-4-(3-nitro-phenyl)-1,4-dihydro-pyrimidine-5-carboxylic acid ethyl ester

1,4-dihydro-6-methyl-4-(3-nitrophenyl)-2-[(phenylmethyl)thio]-5-pyrimidinecarboxylic acid,ethyl ester

ethyl 6-methyl-2-(methylthio)-4-(3-nitrophenyl)-1,4-dihydropyrimidine-5-carboxylate

ethyl 2-(allylthio)-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyrimidine-5-carboxylate