5,5-dimethyl-4-(pyridin-4-yl)-3-(4-(quinolin-2-ylmethoxy)phenyl)-1H-pyrrol-2(5H)-one

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Chemical Name:5,5-dimethyl-4-(pyridin-4-yl)-3-(4-(quinolin-2-ylmethoxy)phenyl)-1H-pyrrol-2(5H)-one
CAS No.:1202367-63-2
Molecular Formula:C₂₇H₂₃N₃O₂
Molecular Weight:421.499
Hs Code.:

Synonyms:5,5-dimethyl-4-(pyridin-4-yl)-3-(4-(quinolin-2-ylmethoxy)phenyl)-1H-pyrrol-2(5H)-one

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Chemical Property of 5,5-dimethyl-4-(pyridin-4-yl)-3-(4-(quinolin-2-ylmethoxy)phenyl)-1H-pyrrol-2(5H)-one

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Technology Process of 5,5-dimethyl-4-(pyridin-4-yl)-3-(4-(quinolin-2-ylmethoxy)phenyl)-1H-pyrrol-2(5H)-one

There total 7 articles about 5,5-dimethyl-4-(pyridin-4-yl)-3-(4-(quinolin-2-ylmethoxy)phenyl)-1H-pyrrol-2(5H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 1202376-36-0
2,2-dimethyl-5-oxo-4-(4-(quinolin-2-ylmethoxy)phenyl)-2,5-dihydro-1H-pyrrol-3-yl trifluoromethanesulfonate

: 1692-15-5
4-pyridylboronic acid

: 1202367-63-2
5,5-dimethyl-4-(pyridin-4-yl)-3-(4-(quinolin-2-ylmethoxy)phenyl)-1H-pyrrol-2(5H)-one

Guidance literature:: 2,2-dimethyl-5-oxo-4-(4-(quinolin-2-ylmethoxy)phenyl)-2,5-dihydro-1H-pyrrol-3-yl trifluoromethanesulfonate; 4-pyridylboronic acid; With sodium carbonate; In 1,4-dioxane; water; at 20 ℃; for 0.5h; Inert atmosphere;

tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; water; at 80 ℃; for 16h;

Reference yield:

: 1202376-34-8
methyl 2-methyl-2-(2-(4-(quinolin-2-ylmethoxy)phenyl)acetamido)propanoate

: 1202367-63-2
5,5-dimethyl-4-(pyridin-4-yl)-3-(4-(quinolin-2-ylmethoxy)phenyl)-1H-pyrrol-2(5H)-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 2 h / 0 °C / Inert atmosphere

2.1: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere

3.1: sodium carbonate / 1,4-dioxane; water / 0.5 h / 20 °C / Inert atmosphere

3.2: 16 h / 80 °C

With sodium hydride; sodium carbonate; triethylamine; In 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; mineral oil; 3.1: Suzuki Coupling;

Reference yield:

: 1202376-35-9
4-hydroxy-5,5-dimethyl-3-(4-(quinolin-2-ylmethoxy)phenyl)-1H-pyrrol-2(5H)-one

: 1202367-63-2
5,5-dimethyl-4-(pyridin-4-yl)-3-(4-(quinolin-2-ylmethoxy)phenyl)-1H-pyrrol-2(5H)-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere

2.1: sodium carbonate / 1,4-dioxane; water / 0.5 h / 20 °C / Inert atmosphere

2.2: 16 h / 80 °C

With sodium carbonate; triethylamine; In 1,4-dioxane; dichloromethane; water; 2.1: Suzuki Coupling;