(R)-ibuprofen butyl ester

Base Information

• Chemical Name: (R)-ibuprofen butyl ester
• CAS No.: 160391-17-3
• Molecular Formula: C₁₇H₂₆O₂
• Molecular Weight: 262.392
• Mol file: 160391-17-3.mol

Synonyms:(R)-ibuprofen butyl ester

Chemical Property of (R)-ibuprofen butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-ibuprofen butyl ester

There total 3 articles about (R)-ibuprofen butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

n-butyl 2-(4-isobutyl-phenyl)propionate (64622-49-7) → (R)-ibuprofen butyl ester (160391-17-3) + (S)-ibuprofen (51146-56-6,58560-75-1)

Guidance literature:

With Candida rugosa lipase immobilized on octyl sepharose; In aq. phosphate buffer; 2,2,4-trimethylpentane; at 50 ℃; for 72h; pH=7; Solvent; Temperature; Concentration; enantioselective reaction; Resolution of racemate; Enzymatic reaction;

DOI:10.1016/j.molcatb.2014.03.005

Reference yield:

ibuprofen (15687-27-1,58560-75-1) → (R)-ibuprofen butyl ester (160391-17-3) + (S)-ibuprofen (51146-56-6,58560-75-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sulfuric acid / toluene; water / Reflux

2: Candida rugosa lipase immobilized on octyl sepharose / aq. phosphate buffer; 2,2,4-trimethylpentane / 72 h / 50 °C / pH 7 / Resolution of racemate; Enzymatic reaction

With sulfuric acid; Candida rugosa lipase immobilized on octyl sepharose; In aq. phosphate buffer; 2,2,4-trimethylpentane; water; toluene;

DOI:10.1016/j.molcatb.2014.03.005

Reference yield:

ibuprofen (15687-27-1,58560-75-1) + butan-1-ol (71-36-3) → butyl 2-[4-(2-methylpropyl)phenyl]propanoate (160391-13-9) + (R)-ibuprofen butyl ester (160391-17-3)

Guidance literature:

With Glauber's salt; sodium sulfate; In cyclohexane; at 30 ℃; for 140h; enantioselective reaction; Molecular sieve; Enzymatic reaction;

DOI:10.1016/j.molcatb.2013.04.008

upstream raw materials:

ibuprofen

butan-1-ol

n-butyl 2-(4-isobutyl-phenyl)propionate