4-(7-bromo-2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-3H-benzo[d]imidazol-5-yl)morpholine

Base Information

Chemical Name:4-(7-bromo-2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-3H-benzo[d]imidazol-5-yl)morpholine
CAS No.:1372540-63-0
Molecular Formula:C₂₁H₂₁BrF₃N₃O
Molecular Weight:468.316
Hs Code.:

Synonyms:4-(7-bromo-2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-3H-benzo[d]imidazol-5-yl)morpholine

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Chemical Property of 4-(7-bromo-2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-3H-benzo[d]imidazol-5-yl)morpholine

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Technology Process of 4-(7-bromo-2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-3H-benzo[d]imidazol-5-yl)morpholine

There total 12 articles about 4-(7-bromo-2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-3H-benzo[d]imidazol-5-yl)morpholine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.0%

: 261952-16-3
1-(bromomethyl)-2-methyl-3-(trifluoromethyl)benzene

: 1372540-59-4
4-(4-bromo-2-methyl-1H-benzo[d]imidazol-6-yl)morpholine

: 1372540-63-0
4-(7-bromo-2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-3H-benzo[d]imidazol-5-yl)morpholine

Guidance literature:: 4-(4-bromo-2-methyl-1H-benzo[d]imidazol-6-yl)morpholine; With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 0.25h;

1-(bromomethyl)-2-methyl-3-(trifluoromethyl)benzene; In N,N-dimethyl-formamide; at 80 ℃; for 3h;

Reference yield:

: 606-22-4
2,6-dinitroaniline

: 1372540-63-0
4-(7-bromo-2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-3H-benzo[d]imidazol-5-yl)morpholine

Guidance literature:: Multi-step reaction with 8 steps

1.1: bromine / acetic acid / 2 h / 120 °C

2.1: diammonium sulfide / ethanol / 2 h / 90 °C

3.1: ethanol; water / 3 h / Reflux

4.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

5.1: caesium carbonate / bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos / 1,4-dioxane / 4 h / 82 °C / Inert atmosphere

6.1: hydrogen / palladium on activated charcoal / ethanol / 50 h / 60 °C / 3040.2 Torr

7.1: water; sodium nitrite; hydrogen bromide / 0.08 h / 0 - 5 °C

7.2: 0.5 h / 60 - 80 °C

8.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C

8.2: 3 h / 80 °C

With diammonium sulfide; water; hydrogen bromide; hydrogen; bromine; potassium carbonate; caesium carbonate; sodium nitrite; palladium on activated charcoal; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In 1,4-dioxane; ethanol; water; acetic acid; N,N-dimethyl-formamide;

Reference yield:

: 84752-20-5
4-bromo-6-nitro-1,2-phenylenediamine

: 1372540-63-0
4-(7-bromo-2-methyl-3-(2-methyl-3-(trifluoromethyl)benzyl)-3H-benzo[d]imidazol-5-yl)morpholine

Guidance literature:: Multi-step reaction with 6 steps

1.1: ethanol; water / 3 h / Reflux

2.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 60 °C

3.1: caesium carbonate / bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos / 1,4-dioxane / 4 h / 82 °C / Inert atmosphere

4.1: hydrogen / palladium on activated charcoal / ethanol / 50 h / 60 °C / 3040.2 Torr

5.1: water; sodium nitrite; hydrogen bromide / 0.08 h / 0 - 5 °C

5.2: 0.5 h / 60 - 80 °C

6.1: potassium carbonate / N,N-dimethyl-formamide / 0.25 h / 20 °C

6.2: 3 h / 80 °C

With water; hydrogen bromide; hydrogen; potassium carbonate; caesium carbonate; sodium nitrite; palladium on activated charcoal; bis(dibenzylideneacetone)-palladium⁽⁰⁾; XPhos; In 1,4-dioxane; ethanol; water; N,N-dimethyl-formamide;