(3RS,4aR,6aS,7R,9aR,9bS)-toluene-4-sulfonic acid 3,9a-dihydroxy-6a-methyldodecahydrocyclopenta[h]isochromen-7-yl ester

Base Information

Chemical Name:(3RS,4aR,6aS,7R,9aR,9bS)-toluene-4-sulfonic acid 3,9a-dihydroxy-6a-methyldodecahydrocyclopenta[h]isochromen-7-yl ester
CAS No.:320594-08-9
Molecular Formula:C₂₀H₂₈O₆S
Molecular Weight:396.505
Hs Code.:

Synonyms:(3RS,4aR,6aS,7R,9aR,9bS)-toluene-4-sulfonic acid 3,9a-dihydroxy-6a-methyldodecahydrocyclopenta[h]isochromen-7-yl ester

Suppliers and Price of (3RS,4aR,6aS,7R,9aR,9bS)-toluene-4-sulfonic acid 3,9a-dihydroxy-6a-methyldodecahydrocyclopenta[h]isochromen-7-yl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3RS,4aR,6aS,7R,9aR,9bS)-toluene-4-sulfonic acid 3,9a-dihydroxy-6a-methyldodecahydrocyclopenta[h]isochromen-7-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3RS,4aR,6aS,7R,9aR,9bS)-toluene-4-sulfonic acid 3,9a-dihydroxy-6a-methyldodecahydrocyclopenta[h]isochromen-7-yl ester

There total 8 articles about (3RS,4aR,6aS,7R,9aR,9bS)-toluene-4-sulfonic acid 3,9a-dihydroxy-6a-methyldodecahydrocyclopenta[h]isochromen-7-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 320594-06-7
(4aR,6aS,7R,9aR,9bS)-toluene-4-sulfonic acid 9a-hydroxy-6a-methyl-3-oxododecahydrocyclopenta[h]isochromen-7-yl ester

: 320594-08-9
(3RS,4aR,6aS,7R,9aR,9bS)-toluene-4-sulfonic acid 3,9a-dihydroxy-6a-methyldodecahydrocyclopenta[h]isochromen-7-yl ester

Guidance literature:: With diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; at -65 ℃; for 0.5h;
DOI:10.1021/jo005582h

Reference yield:

: 168130-60-7
(1R,3aR,4R,5R,7aS)-1-(tert-butyldimethylsilanyloxy)-5-(2,2-dimethoxyethyl)-3a-hydroxy-7a-methyloctahydroindene-4-carbonitrile

: 320594-08-9
(3RS,4aR,6aS,7R,9aR,9bS)-toluene-4-sulfonic acid 3,9a-dihydroxy-6a-methyldodecahydrocyclopenta[h]isochromen-7-yl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: 69 percent / aq. KOH / ethanol / 2 h / 50 °C

2.1: 99 percent / imidazole; DMAP / CH₂Cl₂ / 24 h

3.1: 76 percent / DIBALH / hexane / -60 - 20 °C

4.1: 89 percent / NaBH₄ / ethanol / 1.5 h / -10 °C

5.1: aq. HCl / tetrahydrofuran / 96 h

5.2: 61 percent / Ag₂CO₃ on Celite / benzene / 6 h / Heating

6.1: 92 percent / pyridine / CHCl₃ / 67 h / 20 °C

7.1: 98 percent / DIBALH / CH₂Cl₂; tetrahydrofuran / 0.5 h / -65 °C

With pyridine; 1H-imidazole; hydrogenchloride; dmap; potassium hydroxide; sodium tetrahydroborate; diisobutylaluminium hydride; In tetrahydrofuran; ethanol; hexane; dichloromethane; chloroform;
DOI:10.1021/jo005582h

Reference yield:

: 168130-63-0
(1R,3aR,4S,5R,7aS)-[1-(tert-butyldimethylsilanyloxy)-5-(2,2-dimethoxyethyl)-7a-methyl-3a-(trimethylsilanyloxy)octahydroinden-4-yl]methanol

: 320594-08-9
(3RS,4aR,6aS,7R,9aR,9bS)-toluene-4-sulfonic acid 3,9a-dihydroxy-6a-methyldodecahydrocyclopenta[h]isochromen-7-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: aq. HCl / tetrahydrofuran / 96 h

1.2: 61 percent / Ag₂CO₃ on Celite / benzene / 6 h / Heating

2.1: 92 percent / pyridine / CHCl₃ / 67 h / 20 °C

3.1: 98 percent / DIBALH / CH₂Cl₂; tetrahydrofuran / 0.5 h / -65 °C

With pyridine; hydrogenchloride; diisobutylaluminium hydride; In tetrahydrofuran; dichloromethane; chloroform;
DOI:10.1021/jo005582h